◀ Back to CASP12
CASP12 — CASP8
Text-mined interactions from Literome
Zhuang et al., Exp Cell Res 1999
:
Caspase-8 mediates
caspase-3 activation and cytochrome c release during singlet oxygen induced apoptosis of HL-60 cells
Raoul et al., J Cell Biol 1999
:
Motoneurons resistant to Fas activation expressed high levels of
FLICE-inhibitory protein (FLIP) , an endogenous
inhibitor of
caspase-8 activation
Okamoto et al., Rheumatology (Oxford) 2000
(Arthritis, Rheumatoid) :
Caspase-8-specific inhibitor
suppressed the activation of
caspase-3 after Fas ligation on RA synoviocytes
Hernandez et al., Surgery 2001
(Colonic Neoplasms) :
Western blots were performed to assess intracellular expression of
Flice-like inhibitory protein (FLIP) , a
caspase inhibitor
Kilic et al., Cell Death Differ 2002
:
Formation of noncanonical high molecular weight
caspase-3 and -6 complexes and
activation of
caspase-12 during serum starvation induced apoptosis in AKR-2B mouse fibroblasts
Feng et al., Am J Physiol Gastrointest Liver Physiol 2002
(Necrosis) :
Caspase-3 was activated in primary hepatocytes by STS treatment, but
caspase-9 and -12 were not
activated , and
caspase-3 activation is not dependent on caspase-8
Morishima et al., J Biol Chem 2002
:
Cytochrome c-independent
activation of
caspase-9 by
caspase-12 ... These results suggest that
caspase-12 can
activate caspase-9 without involvement of cytochrome c
Thomas et al., Surgery 2002
(Pancreatic Neoplasms) :
FLICE-like inhibitory protein (FLIP) , an
inhibitor of
caspase-8 , ( also known as FLICE ) is regulated by the transcription factor nuclear factor-kappaB (NF-kappaB) and can contribute to TRAIL resistance
Chan et al., Neurobiol Dis 2002
(Alzheimer Disease) :
Moreover,
activation of
caspase-12 , an endoplasmic reticulum ( ER ) -associated
caspase , is greatly increased in cells expressing mutant PS1
Xu et al., Anticancer Res 2003
(Pancreatic Neoplasms) :
Caspase-8 and -3 activities were increased by TRAIL treatment and apoptosis was largely
blocked by
caspase-8 and -3 inhibitors
Fujii et al., Infect Immun 2003
:
Caspase-8 is known to activate Bid, and a specific inhibitor of
caspase-8 prevented the mitochondrial damage
Perchellet et al., Anticancer Drugs 2004
:
Caspase-2 and -8 may both act upstream of mitochondria to promote Cyt c release, but
caspase-2 is already maximally
activated 6 h after 4 microM DAU or TT13 treatments, whereas DAU- or TT-induced caspase-8 and -9 activities peak at 9 h. Pre-treatments with 15 microM of the caspase-2 inhibitor benzyloxycarbonyl ( z ) -Val-Asp-Val-Ala-Asp ( VDVAD ) -fluoromethyl ketone ( fmk ) totally block DAU- and TT13 induced caspase-2, -8 and -9 activities, whereas pre-treatments with 15 microM of the caspase-8 inhibitor z-Ile-Glu-Thr-Asp ( IETD ) -fmk prevent DAU and TT13 from inducing caspase-8 activities without affecting their caspase-2- and -9-inducing activities, suggesting that the induction of apical caspase-2 activity by these drugs may be a critical upstream event required for the activation of other downstream caspases, including caspase-9 and the mitochondrial amplification loop through caspase-8
Aoyama et al., J Cereb Blood Flow Metab 2005
(Acidosis) :
Acidosis also increased caspase-12 mRNA expression, caspase-12 protein expression, cleavage of
caspase-12 to its active form, and
activation of
caspase-3
Obeng et al., J Biol Chem 2005
:
We further demonstrate that ER stress induced apoptosis is a caspase dependent process that does not require the expression of
caspase-12 or caspase-4 but can be
inhibited by overexpression of Bcl-x ( L ) or a dominant negative
caspase-9
Maitra et al., Crit Care Med 2005
(Sepsis) :
Caspase-8 activates
caspase-3 , which in turn degrades fibronectin and focal adhesion kinase and leads to disruption of hepatic architecture and integrity
Miyao et al., Otol Neurotol 2006
(Cholesteatoma, Middle Ear) :
Caspase-8 , which is activated by the induction of tumor necrosis factor-alpha,
leads to activation of
caspase-3 , which activates apoptotic nucleases
Nakano et al., Cardiovasc Res 2006
:
A non-selective
caspase inhibitor, z-VAD.fmk ( 100 microM ),
inhibited apoptosis and cleavage of
caspase-12 stimulated by thapsigargin, while a calpain inhibitor, MDL 28170 ( 120 microM ), inhibited caspase-12 cleavage but not apoptosis
Cervia et al., Apoptosis 2006
(Pituitary Neoplasms) :
In addition, we provide evidence that euplotin C treatment results in rapid activation of ryanodine receptors, depletion of Ca2+ stores in the endoplasmic reticulum ( ER ), the release of cytochrome c from the mitochondria,
activation of
caspase-12 , and activation of
caspase-3 , leading to apoptosis
Wu et al., Cell Mol Life Sci 2006
:
Caspase-8 played important roles in the activation of
caspase-3 and induction of apoptosis, whereas the role of the caspase-9 was limited
Yamaguchi et al., Biochim Biophys Acta 2006
(Carcinoma, Hepatocellular...) :
We demonstrated that
Adv-Casp8 increased expression of active forms of
caspase-8 in MOI dependent manner
Kumar et al., Cardiovasc Res 2007
(Acidosis...) :
Simulated ischemia had no significant effect on caspase-8 cleavage, but induced cleavage of
caspase-3 and caspase-12 and led to a slight release of cytochrome C. Prevention of cytosolic acidosis ( anoxia at pH ( o ) 7.4 ) had no effect on cytochrome C release, but significantly reduced apoptosis, attenuated cytosolic Ca2+ overload, and
prevented cleavage of
caspase-12
Fábián et al., J Virol 2007
(Carcinoma...) :
While
caspase-8 and caspase-9 are not involved in MTH-68/H induced apoptosis, activation of caspase-3 and
caspase-12 was
detected in virus infected PC12 cells
Faragher et al., Mol Biol Cell 2007
(Breast Neoplasms) :
Caspase-8 activates cytoplasmic
caspase-7 , which is likely to be the primary caspase responsible for cleavage of CENP-C and INCENP, a key chromosomal passenger protein
Lin et al., Biochem Biophys Res Commun 2007
(Spinocerebellar Ataxias) :
PKCgamma SCA14 mutant proteins were shown to cause aggregation which initially resulted in endoplasmic reticulum ( ER ) stress and cell apoptosis as demonstrated by phosphorylation of PERK on Thr981,
activation of
caspase-12 , increases in BiP/GRP78 protein levels, and consequent activation of
caspase-3
Pesakhov et al., Nutr Cancer 2010
(Leukemia, Myeloid, Acute) :
Caspase-8 inhibition abrogated Bid cleavage and strongly
reduced caspase-9 activation, suggesting that the cross-talk mechanism mediated by caspase-8 dependent Bid cleavage can contribute to the activation of the intrinsic apoptotic pathway by curcumin + carnosic acid
Park et al., Biochem Pharmacol 2011
:
Further analysis using selective caspase inhibitors revealed that
caspase-12 activation was
required for activation of
caspase-9 and -3 to the sufficient level for subsequent activation of caspase-7 and -8
Moujalled et al., Cell Death Differ 2012
:
In mouse embryonic fibroblasts, neither caspase-8 nor cellular
FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-?B, but
caspase-8 is
required for TNF to cause cell death, and induction of FLIP by NF-?B is required to prevent it
Sata et al., J Biol Chem 1998
:
Here, we show that endothelial cell apoptosis by OxLDL and LPC-C16 : 0 was dose dependent and correlated with down-regulation of
FLICE-inhibitory protein (FLIP) , an intracellular
caspase inhibitor
Yamashita et al., Blood 1999
:
Caspase-8 activated
caspase-3 and T18 in neutrophil cytoplasmic extracts