◀ Back to TRAF6

TRAF3IP2 — TRAF6

Pathways - manually collected, often from reviews:

• WikiPathways IL17 signaling pathway: TRAF3IP2 → TRAF6 (activation)
• WikiPathways IL17 signaling pathway: TRAF3IP2 → TRAF6 (activation)
• WikiPathways IL17 signaling pathway: TRAF3IP2 → TRAF6 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TRAF6 — TRAF3IP2 (direct interaction, two hybrid) Kanamori et al., FEBS Lett 2002*
• IRef Biogrid Interaction: TRAF6 — TRAF3IP2 (direct interaction, pull down) Kanamori et al., FEBS Lett 2002*
• IRef Biogrid Interaction: TRAF6 — TRAF3IP2 (physical association, affinity chromatography technology) Kanamori et al., FEBS Lett 2002*
• IRef Biogrid Interaction: TRAF6 — TRAF3IP2 (physical association, affinity chromatography technology) Qian et al., Nat Immunol 2007*
• IRef Biogrid Interaction: TRAF6 — TRAF3IP2 (physical association, affinity chromatography technology) Qu et al., Mol Cell Biol 2012*
• IRef Biogrid Interaction: TRAF6 — TRAF3IP2 (direct interaction, enzymatic study) Liu et al., Science signaling 2009*
• IRef Hprd Interaction: TRAF6 — TRAF3IP2 (in vitro) Kanamori et al., FEBS Lett 2002*
• IRef Hprd Interaction: TRAF6 — TRAF3IP2 (in vivo) Kanamori et al., FEBS Lett 2002*
• IRef Innatedb Interaction: Complex of IL17RA-TRAF6-TRAF3IP2-IL17RA-TRAF6-TRAF3IP2 (unknown, -) Qian et al., Nat Immunol 2007*
• IRef Innatedb Interaction: TRAF6 — TRAF3IP2 (unknown, -) Liu et al., Science signaling 2009*
• IRef Intact Interaction: TRAF6 — TRAF3IP2 (physical association, two hybrid) Yu et al., Nat Methods 2011
• IRef Intact Interaction: TRAF6 — TRAF3IP2 (physical association, two hybrid) Hüffmeier et al., Nat Genet 2010*
• IRef Ophid Interaction: TRAF6 — TRAF3IP2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: TRAF6 — TRAF3IP2 (aggregation, confirmational text mining) Kanamori et al., FEBS Lett 2002*

Text-mined interactions from Literome

Qu et al., Mol Cell Biol 2012 : TRAF6 dependent Act1 phosphorylation by the I?B kinase related kinases suppresses interleukin-17 induced NF-?B activation ... Act1 phosphorylation on the three sites inhibited its association with TRAF6 and consequently NF-?B activation in IL-17R signaling ... Interestingly, TRAF6 , but not TRAF3, which is the upstream adaptor of the IKK related kinases in antiviral signaling, was critical for IL-17 induced Act1 phosphorylation ... TRAF6 was essential for IL-17 induced TBK1 activation, its association with Act1 , and consequent Act1 phosphorylation ... Our findings define a new role for the IKK related kinases in suppressing IL-17 mediated NF-?B activation through TRAF6 dependent Act1 phosphorylation
Zhong et al., Nat Immunol 2012 (Inflammation) : Mechanistically, stimulation with IL-17 induced the association of USP25 with the adaptors TRAF5 and TRAF6, and USP25 induced removal of Lys63 linked ubiquitination in TRAF5 and TRAF6 mediated by the adaptor Act1