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RELA — TNFSF12

Text-mined interactions from Literome

Schneider et al., Eur J Immunol 1999 : In contrast to TNF, TWEAK does only modestly activate NF-kappaB or c-jun N-terminal kinase ( JNK ) in Kym-1 cells
Han et al., Biochem Biophys Res Commun 2003 : TNF related weak inducer of apoptosis receptor, a TNF receptor superfamily member, activates NF-kappa B through TNF receptor associated factors
Saitoh et al., J Biol Chem 2003 : TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB activation ... Unlike TNF-alpha, TWEAK stimulation results in prolonged NF-kappaB activation with a transition of the DNA binding NF-kappaB components from RelA- to RelB containing complexes by 8 h, and the latter remained active in binding at least until 24 h post-stimulation
De Ketelaere et al., FEBS Lett 2004 : Involvement of GSK-3beta in TWEAK mediated NF-kappaB activation
Potrovita et al., J Neurosci 2004 (Brain Ischemia...) : Transfection of a nuclear factor (NF)-kappaB-luciferase fusion gene demonstrated that TWEAK stimulated transcriptional activity of NF-kappaB through Fn14 and the IkappaB kinase
Tran et al., Cancer Res 2006 (Brain Neoplasms...) : Activation of Fn14 signaling by the ligand TNF-like weak inducer of apoptosis ( TWEAK ) stimulates migration and up-regulates expression of Fn14 ; this TWEAK effect requires Rac1 and nuclear factor-kappaB (NF-kappaB) activity
Dogra et al., FASEB J 2007 (Body Weight...) : Furthermore, TWEAK increased the activation of NF-kappaB transcription factor in myotubes
Yepes et al., Mol Neurobiol 2007 (Brain Edema...) : Furthermore, there is a growing body of evidence indicating that TWEAK induces the activation of the NF-kappaB in the CNS with release of proinflammatory cytokines and matrix metalloproteinases
Sanz et al., J Am Soc Nephrol 2008 (Nephritis, Interstitial) : In vitro, it was found that TWEAK induced the sustained activation of NF-kappaB in a murine tubular epithelial cell line ( MCT ) ... Parthenolide, which prevents IkappaB-alpha degradation, inhibited TWEAK induced NF-kappaB activation and prevented the aforementioned changes in vitro and in vivo
Kumar et al., J Immunol 2009 (Inflammation) : In this study, we tested the hypothesis that TAK1 ( TGF-beta activated kinase 1 ) is involved in TWEAK induced activation of NF-kappaB and MAPK and expression of proinflammatory protein ... Furthermore, TWEAK induced transcriptional activation of NF-kappaB was significantly reduced in TAK1 ( -/- ) MEF and in C2C12 myoblasts transfected with a dominant negative TAK1 or TAK1 short interfering RNA
Ebihara et al., Exp Eye Res 2009 : TWEAK induced phosphorylation of NF-kappaB and MAP kinase in corneal myofibroblasts
Sanz et al., PloS one 2010 : It has previously been reported that TWEAK induces transient nuclear translocation of RelA and expression of RelA dependent cytokines in renal tubular cells ... We now explore TWEAK induced activation of NFkappaB2 and RelB, as well as expression of CCL21, a T-cell chemotactic factor, in cultured murine tubular epithelial cells and in healthy kidneys in vivo ... In cultured tubular cells, TWEAK and TNFalpha activated different DNA binding NFkappaB complexes ... In vivo, TWEAK induced nuclear NFkappaB2 and RelB translocation and CCL21a mRNA ( 1.5+/-0.3-fold over control ) and CCL21 protein ( 1.6+/-0.5-fold over control ) expression in normal kidney
Moreno et al., J Am Soc Nephrol 2011 (Acute Kidney Injury) : Inhibition of histone deacetylase reversed TWEAK induced downregulation of Klotho, and chromatin immunoprecipitation showed that TWEAK promotes RelA binding to the Klotho promoter, inducing its deacetylation