◀ Back to SETD2
PTGS2 — SETD2
Text-mined interactions from Literome
Csiki et al., Cancer Res 2006
(Carcinoma, Non-Small-Cell Lung...) :
In this study, we sought to determine the
role of
HIF-1 in the induction of
COX-2 expression during hypoxia
Kaidi et al., Cancer Res 2006
(Colorectal Neoplasms...) :
Direct transcriptional up-regulation of
cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and
enhances HIF-1 transcriptional activity during hypoxia ... This study identifies
COX-2 as a direct
target for
HIF-1 in colorectal tumor cells
Gu et al., Zhongguo Fei Ai Za Zhi 2011
(Adenocarcinoma...) :
The overexpression of
HIF-1a may
induce the overexpression of
COX-2 , and is non correlated with expression of E-cadherin
Zuloaga et al., Am J Physiol Heart Circ Physiol 2011
:
Since
hypoxia inducible factor-1a (HIF-1a) activation can
lead to
COX-2 production, this study determined the influence of DHT on HIF-1a and COX-2 following hypoxia or hypoxia with glucose deprivation (HGD) in the cerebral vasculature
Wu et al., J Pathol 2011
(Endometriosis) :
In contrast, forced expression of DUSP2 under hypoxia abolishes
HIF-1a induced ERK phosphorylation and
COX-2 expression
Hari Kishore et al., Mol Endocrinol 2012
:
We also show that activation of
HIF-1a induced
cyclooxygenase-2 and that prostaglandin E ( 2 ) repressed MiTF-CX
Garufi et al., PloS one 2012
:
Here, zinc supplementation to HIPK2 depleted cells inhibited
HIF-1 induced
COX-2 expression and PGE ( 2 ) /VEGF production ... THESE FINDINGS SHOW THAT : 1 ) HIPK2 knockdown induced COX-2 upregulation, mostly depending on HIF-1 activity ; 2 ) zinc treatment downregulated
HIF-1 induced
COX-2 and inhibited PGE ( 2 ) /VEGF production ; and 3 ) zinc treatment of HIPK2 depleted cells restored DCs maturation