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ALK — SMAD3

Text-mined interactions from Literome

Bernard et al., Mol Endocrinol 2004 : Because SMAD7 functions by preventing access of SMAD2 and SMAD3 to ALK4, these data suggested that both activins and ALK4 require SMAD2 and/or SMAD3 to affect FSHbeta transcription
DaCosta Byfield et al., Mol Pharmacol 2004 : We demonstrate that this compound selectively and concentration-dependently inhibits ALK4-, ALK5-, and ALK 7-dependent activation of downstream cytoplasmic signal transducers, Smad2 and Smad3, and of TGF-beta induced mitogen activated protein kinase pathway components but does not alter ALK1, ALK2, ALK3 or ALK6 induced Smad signaling
Besser et al., J Biol Chem 2004 : Treatment of differentiating cells with Activin A leads to activation of Smad2/3 and expression of nodal, lefty-A and lefty-B, while inhibition of ALK4/5/7 by the kinase inhibitor SB-431542 blocks activation of Smad2/3 and expression of these genes in the undifferentiated state
Bernard et al., Reproductive biology and endocrinology : RB&E 2006 : Transfection of both ALK4 ( TD ) and ALK7 ( TD ) stimulated Smad2/3 phosphorylation, and the effects of both receptors on Fshb promoter activity were inhibited by depletion of endogenous Smad3 protein levels
Esguerra et al., Development 2007 : Stimulation of Alk4/EGF-CFC receptor complexes by Nodal activates Smad2/3 , leading to left sided expression of target genes that promote asymmetric placement of certain internal organs
Miyake et al., Anim Sci J 2010 : An activin-like kinase (ALK) inhibitor, SB431542, mediates MSTN action, suppressed the translocation of Smad2/3 into the nucleus in DM-myoblasts, and restored the attenuated IGF-2 mRNA expression and the decreased myotube formation induced by rMSTN in myoblast cultures
Luo et al., J Biol Chem 2010 : Likewise, RNAi silencing of ALK1 and ALK2 expression inhibits BMP9 induced BMPR-Smad activity and osteogenic differentiation in MSCs both in vitro and in vivo
Watanabe et al., Biochem Biophys Res Commun 1999 : These results indicate that the ALK7 signal regulates nuclear localization and activation of Smad2 and Smad3 , and the MH1 domain of Smad2 has inhibitory effects on the nuclear localization