Ammosova et al., J Biol Chem 2003
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We recently reported that protein phosphatase 1 (PP1) dephosphorylates RNA polymerase II C-terminal repeats and regulates HIV-1 transcription in vitro ... Here we provide evidence that PP1 is also required for Tat induced HIV-1 transcription and for viral replication in cultured cells ... Inhibition of PP1 by overexpression of nuclear inhibitor of PP1 (NIPP1) inhibited Tat induced HIV-1 transcription in transient transfection assays
Ammosova et al., Retrovirology 2005
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Our results indicate that although PP2A dephosphorylates autophosphorylated CDK9 in vitro, in cultured cells PP1 is likely to dephosphorylate CDK9 and contribute to the regulation of activated HIV-1 transcription Ammosova et al., J Biol Chem 2005
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We previously showed that Tat induced HIV-1 transcription is regulated by protein phosphatase-1 (PP1) ... Our results suggest that Tat might function as a nuclear regulator of PP1 and that interaction of Tat with PP1 is critical for activation of HIV-1 transcription by Tat
Nekhai et al., Curr HIV Res 2007
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We have shown that HIV-1 Tat binds PP1 in vitro ; targets PP1 to the nucleus ; and that Tat interaction with PP1 is important for HIV-1 transcription Ammosova et al., J Biol Chem 2011
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The stable expression of cdNIPP1 disrupted the interaction of Tat and PP1 and inhibited HIV-1 transcription Ammosova et al., PloS one 2012
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We showed that expression of PP1 binding peptide, a central domain of Nuclear Inhibitor of PP1, disrupted the interaction of HIV-1 Tat with PP1 and inhibited HIV-1 transcription and replication