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FGF1 — GAB1

Pathways - manually collected, often from reviews:

• Reactome Reaction: FGF1 → GAB1 (reaction) Ong et al., Proc Natl Acad Sci U S A 2001, Guasch et al., Mol Cell Biol 2001, Demiroglu et al., Blood 2001, Agazie et al., Oncogene 2003, Chen et al., Proc Natl Acad Sci U S A 2004, Takeda et al., Clin Cancer Res 2007, Kunii et al., Cancer Res 2008, Byron et al., Cancer Res 2008, Taylor et al., J Clin Invest 2009, Weiss et al., Sci Transl Med 2010, Dutt et al., PloS one 2011, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998
• Reactome Reaction: FGF1 → GAB1 (indirect_complex) Ong et al., Proc Natl Acad Sci U S A 2001, Guasch et al., Mol Cell Biol 2001, Demiroglu et al., Blood 2001, Agazie et al., Oncogene 2003, Chen et al., Proc Natl Acad Sci U S A 2004, Takeda et al., Clin Cancer Res 2007, Kunii et al., Cancer Res 2008, Byron et al., Cancer Res 2008, Taylor et al., J Clin Invest 2009, Weiss et al., Sci Transl Med 2010, Dutt et al., PloS one 2011, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998

Text-mined interactions from Literome

Ong et al., Proc Natl Acad Sci U S A 2001 : Assembly of FRS2alpha : Grb2 : Gab1 complex induced by FGF stimulation results in activation of PI3-kinase and downstream effector proteins such as the S/T kinase Akt, whose cellular localization and activity are regulated by products of PI3-kinase
Lamothe et al., Mol Cell Biol 2004 : In this report, we explore the role of Gab1 in FGF1 signaling by using mouse embryo fibroblasts ( MEFs ) derived from Gab1 ( -/- ) or FRS2alpha ( -/- ) mice ... We demonstrate that Gab1 is essential for FGF1 stimulation of both PI 3-kinase and the antiapoptotic protein kinase Akt, while FGF1 induced mitogen activated protein kinase ( MAPK ) stimulation is not affected by Gab1 deficiency ... These experiments underscore the essential role of Gab1 in FGF1 stimulation of the PI 3-kinase/Akt signaling pathway and provide further support for the indirect mechanism for FGF1 stimulation of PI 3-kinase involving regulated assembly of a multiprotein complex