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ADRA2A — EPHB2

Text-mined interactions from Literome

Pierce et al., Proc Natl Acad Sci U S A 2000 : Surprisingly, we found that in COS-7 cells, ERK activation by the alpha(2A) AR , like that mediated by both the beta ( 2 ) AR and the epidermal growth factor receptor (EGFR), is sensitive to mechanistically distinct inhibitors of clathrin mediated endocytosis, including monodansylcadaverine, a mutant dynamin I, and a mutant beta-arrestin 1
Feldman et al., J Biol Chem 2002 : In contrast, alpha(2A)AR mediated ERK activation in COS-7 cells was enhanced by GsCT expression, consistent with the relief of a downstream inhibitory effect of PKA
Buffin-Meyer et al., Eur J Pharmacol 2007 : In conclusion, alpha(2A)-adrenoreceptor activates ERK and Akt in intestinal cells by a common pathway which depends on PI3-kinase activation and results from EGF receptor transactivation, via an autocrine/paracrine pathway implying MMP activation and heparin-binding-EGF shedding