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CXCL10 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CXCL10 → TNF (increases)
  Evidence: the CXC chemokines Mig and interferon-? inducible protein 10 can be expressed and bound by endothelium stimulated with interferon-? and tumor necrosis factor (TNF) ?, and can induce the firm adhesion of T lymphocyte in shear flow via CXCR3.

Text-mined interactions from Literome

Sauty et al., J Immunol 1999 : We found that IFN-gamma, but not TNF-alpha or IL-1 beta, strongly induced IP-10 , Mig, and I-TAC mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types
Ortego et al., Atherosclerosis 1999 (Coronary Artery Disease...) : Ang II and TNF-alpha induced the expression of IP-10 ( 1.5 and 3.4-fold ) and MCP-1 ( 2.4 and 4-fold ) in VSMC
Narumi et al., Cytokine 2000 : Pretreatment with GM-CSF selectively inhibited IL-1beta, but not TNF-alpha induced IP-10 mRNA expression ... Our results demonstrated that chemokine induction is stimulus-, tissue- and cell type-specific and that IP-10 ( but not MCP-1 ) is inducible in hepatocytes by TNF-alpha most potently, even in the presence of GM-CSF, suggesting the specific role of TNF-alpha induced IP-10 on intralobular mononuclear infiltration in chronic hepatitis
Albanesi et al., J Immunol 2000 (Calcium Signaling...) : IL-4, but not IL-10 or IL-17, significantly up-regulated IFN-gamma- or TNF-alpha induced IP-10 , Mig, and I-TAC mRNA accumulation in keratinocytes and increased the levels of IP-10 and Mig in keratinocyte supernatants
Frangogiannis et al., Cell Tissue Res 2000 (Endotoxemia) : TNF-alpha , IL-1 beta, and M-CSF are potent inducers of IP-10 in canine endothelial cells and may indirectly mediate lymphocyte chemotaxis and activation in inflammatory processes
Palma et al., J Neuroimmunol 2001 (Inflammation) : Both RANTES and IP-10 were stimulated by proinflammatory cytokine interferon-gamma (IFNgamma), but only RANTES by tumor necrosis factor alpha (TNFalpha) , suggesting that virus infection induces chemokines overlapping with those inducible by proinflammatory cytokines
Romagnani et al., J Am Soc Nephrol 2002 (Kidney Diseases) : The induction of IP-10 and Mig mRNA and protein expression by IFN-gamma plus TNF-alpha was strongly inhibited by nitric oxide ( NO ) donors, such as sodium nitroprusside or S-nitroso-N-acetylpenicillamine, but not by cGMP analogues ... Electrophoretic mobility shift assays demonstrated that NO donors repressed IP-10 gene transcription induced by IFN-gamma plus TNF-alpha through the inhibition of NF-kappaB activation
Sheikh et al., Ann N Y Acad Sci 2001 : Lyso-PC inhibited IFN-gamma or IFN-gamma plus TNF-alpha induced IP-10 , Mig, and I-TAC mRNA expression but not that of the IRF-1 or IRF-1 dependent molecule, GBP
Cheng et al., J Immunol 2002 : We found that incubation of human dermal microvascular endothelial cells with recombinant eotaxin/CCL11 suppresses TNF-alpha induced production of the neutrophil-specific chemokine IL-8/CXCL8
Nakae et al., Int Immunol 2003 (Dermatitis, Contact...) : Although IP-10 mRNA expression was abrogated in TNF-alpha ( -/- ) mice, both CHS development and TNF-alpha mRNA expression occurred normally in IFN-gamma ( -/- ) mice, indicating that the induction of IP-10 during CHS was primarily controlled by TNF-alpha
Kallapur et al., Am J Respir Crit Care Med 2003 (Bronchopulmonary Dysplasia...) : In contrast to endotoxin, IA tumor necrosis factor-alpha or interleukin-1 alpha did not induce IP-10 or MIG mRNA in the lung
Hardaker et al., FASEB J 2004 (Inflammation...) : In primary cultured hASM cells taken from normal donors, CXCL10 protein expression was induced by IFN-gamma and TNF-alpha , cytokines reported as elevated in COPD, and a synergistic response was obtained when they were combined ... TNF-alpha induced CXCL10 expression in hASM was dependent on NFkappaB activation, and a salicylanilide NFkappaB inhibitor blocked the CXCL10 expression
Juarranz et al., Rheumatology (Oxford) 2004 (Arthritis, Rheumatoid...) : The effects of VIP on basal or tumour necrosis factor alpha (TNF-alpha) stimulated production of CCL2 ( MCP-1, monocyte chemotactic protein 1 ), CXCL8 [ interleukin (IL)-8 ], IL-6 and TNF-alpha were studied by specific ELISAs ( enzyme linked immunosorbent assays )
Villagomez et al., Br J Dermatol 2004 (Dermatitis, Atopic) : TNF-alpha is the main inducer of IP-10 by skin fibroblasts, but not IFN-gamma or IL-4
Dajotoy et al., J Leukoc Biol 2004 (Crohn Disease) : TNF-alpha but not IL-1beta enhanced the IFN-gamma induced production of MIG and IP-10
Lang et al., Clin Nutr 2004 : The spontaneous and TNF-alpha stimulated secretion of IL-1beta, IL-8, IP-10 and MIG from HT-29 and Caco-2 cells was tested with, or without pretreatment with allicin
Secchiero et al., Blood 2005 (Inflammation) : TRAIL pretreatment variably down modulated the mRNA steady-state levels of several TNF-alpha induced chemokines, and, in particular, it abrogated the TNF-alpha mediated up-regulation of CCL8 and CXCL10
McInnis et al., Invest Ophthalmol Vis Sci 2005 : IP-10 synthesis is induced in HCKs by IL-1alpha, TNF-alpha , and IFN-gamma
Inatomi et al., J Gastroenterol 2005 : Tumor necrosis factor (TNF)-alpha also stimulated IP-10 mRNA expression, but this was much weaker than that induced by IFN-gamma ... Trichostatin A, a specific inhibitor of histone deacetylase, also blocked the IFN-gamma- and TNF-alpha induced IP-10 mRNA expression, but the effects of trichostatin A were weaker than those of butyrate
Berthier-Vergnes et al., FEBS Lett 2005 (Hypersensitivity) : TNF-alpha enhances phenotypic and functional maturation of human epidermal Langerhans cells and induces IL-12 p40 and IP-10/CXCL-10 production ... More importantly, TNF-alpha induced LC to produce both IFN-gamma-inducible-protein IP-10/CXCL10 , a Th1 attracting chemokine and IL-12 p40
Yamada et al., J Urol 2005 (Urinary Bladder Neoplasms) : Previously we have reported that RT4, a well differentiated human bladder cancer line, increases the expression of macrophage derived chemokine (MDC) and interferon (IFN)-gamma-inducible protein-10 ( IP-10 ) in response to IFN-gamma and tumor necrosis factor (TNF)-alpha
Antonelli et al., J Clin Endocrinol Metab 2006 (Graves Ophthalmopathy) : In primary cultures of thyrocytes, retrobulbar fibroblasts and retrobulbar preadipocytes from GO patients, CXCL10 production was absent under basal conditions ; dose dependent secretion of CXCL10 was not induced by TNFalpha alone, whereas stimulation with IFNgamma or TNFalpha plus IFNgamma induced CXCL10 release ... Treatment of all cell types with the PPARgamma agonist, rosiglitazone, dose-dependently ( 0.1-10 microm ) suppressed IFNgamma- plus TNFalpha induced CXCL10 release
Wong et al., Allergy 2006 : Either SCF or TNF-alpha could induce release from HMC-1 cells of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, regulated upon activation normal T-cell expressed and secreted ( RANTES ), and I-309, while SCF and TNF-alpha induced release of macrophage inflammatory protein (MIP)-1beta and interferon-gamma-inducible protein-10 (IP-10) , respectively ... Using various selective inhibitors for signaling molecules, we found that the inductions of IL-8, MCP-1, and I-309 were mediated by either SCF activated ERK or TNF-alpha activated p38 MAPK, while the induction of IP-10 by TNF-alpha was mediated by both activated p38 MAPK and NF-kappaB
Green et al., J Infect Dis 2006 : Analysis of > 1500 ARE containing cellular mRNAs, by use of microarrays, revealed that CXCL-8 and other newly identified ARE genes were induced by TNF- alpha in Huh7 cells and were coordinately regulated
Ruiz et al., J Nutr 2006 (Inflammation) : We demonstrated that 3'-hydroxy-flavone but not the chemical core structure flavone blocked TNF-alpha induced nuclear factor (NF)-kappaB transcriptional activity and IP-10 expression at the level of NF-kappaB/IkappaBalpha phosphorylation/degradation by inhibiting IkappaB kinase activity
De Plaen et al., Immunology 2006 : In conclusion, CXCL2 gene is expressed in enterocytes in response to both TNF and LPS
Leonardi et al., Clin Exp Allergy 2006 (Conjunctivitis, Allergic) : By PCR, fibroblasts expressed MCP-1 transcripts constitutively, whereas IP-10 and Mig were up-regulated by TNF-alpha
Yang et al., Vet Immunol Immunopathol 2007 : Molecular characterization of cDNA encoding porcine IP-10 and induction of porcine endothelial IP-10 in response to human TNF-alpha
Ruiz et al., J Nutr 2007 (Ileitis) : Quercetin inhibited TNF induced interferon-gamma-inducible protein 10 ( IP-10 ) and macrophage inflammatory protein 2 ( MIP-2 ) gene expression in Mode-K cells with effective inhibitory concentration of 40 and 44 micromol/L, respectively
Kamohara et al., Int J Oncol 2007 (Inflammation...) : Induction of interleukin-8 ( CXCL-8 ) by tumor necrosis factor-alpha and leukemia inhibitory factor in pancreatic carcinoma cells : Impact of CXCL-8 as an autocrine growth factor
McInnis et al., Ocul Immunol Inflamm 2007 : Stimulation of HCE with either IL-1alpha or TNF-alpha increased IP-10 protein synthesis up to 6-fold, whereas insignificant levels of MIG and I-TAC were induced
Crescioli et al., J Endocrinol 2007 (Goiter, Nodular) : In human thyrocytes, the synergistic effect of TNFalpha with IFNgamma on CXCL10 secretion is due to the upregulation of IFNgamma receptor expression
Lombardi et al., Arterioscler Thromb Vasc Biol 2008 (Inflammation...) : TNFalpha and IFNgamma, mainly when combined, stimulate IFNgamma-inducible protein of 10 kDa (IP10) and fractalkine production evaluated by ELISA and TaqMan analyses
Borgogni et al., Endocrinology 2008 : In human thyrocytes, elocalcitol inhibited IFNgamma and TNFalpha induced CXCL10 protein secretion more potently than MMI
Hosokawa et al., Clin Exp Immunol 2008 (Chronic Disease...) : We revealed that TNF-alpha stimulation induced CXCL10 production by HGFs. HGFs expressed AM and AM receptors, calcitonin-receptor-like receptor (CRLR) and receptor-activity modifying protein ( RAMP) 2, mRNAs constitutively
Sumida et al., Arch Med Res 2008 (Lung Diseases, Interstitial) : However, the induction patterns of chemokines by these two cytokines were different, i.e., involving predominant induction of IP-10 and I-TAC by TNF-alpha and induction of Mig by IFN-gamma
Funakoshi-Tago et al., Biochem Pharmacol 2008 : As a result, TNFalpha induced expression of inflammatory cytokines, CXCL1/KC and CCL2/MCP-1, was clearly inhibited by Celecoxib
Enríquez-de-Salamanca et al., Cytokine 2008 (Conjunctivitis, Allergic...) : After 48 h, TNF-alpha also induced a significant increase in IL-1beta, IL-3, and IP-10 secretion
Lee et al., J Immunol 2008 : IL-17 strongly repressed TNF-alpha stimulated expression of CXCL10, CXCL11, and CCL5, but synergized with TNF-alpha for induction of CXCL8 , CXCL1, and CCL20 mRNAs
Hosokawa et al., J Periodontal Res 2009 (Periodontitis) : Human gingival fibroblasts produced CXCL10 protein upon stimulation with interleukin-1beta, tumor necrosis factor-alpha and interferon-gamma
Ohta et al., J Dent Res 2008 : In contrast, TNF-alpha caused an increase in CXCL9 ( 300-fold ), CXCL10 ( 2000-fold ), and CXCL11 ( 2000-fold ) mRNA levels in GT1, but not RT7 cells, at 24 hrs
Funakoshi-Tago et al., Cytokine 2009 : Interestingly, we observed that TNFalpha induced expression of IL-6, CXCL1 and granulocyte macrophage colony stimulating factor ( GM-CSF ) were significantly enhanced in TRAF6-deficient MEFs
Hoermannsperger et al., PloS one 2009 (Chronic Disease...) : Interestingly, L. casei failed to block TNF induced IP-10 promoter activity or IP-10 gene transcription at the mRNA expression level but completely inhibited IP-10 protein secretion as well as IP-10 mediated T-cell transmigration
Subileau et al., J Neuropathol Exp Neurol 2009 (Inflammation...) : Tumor necrosis factor strongly increased the production of CCL2, CCL5, and CXCL8 ; interferon gamma upregulated CXCL10 exclusively
Heuvelin et al., PloS one 2009 (Colitis) : TNFalpha induced chemokine ( CXCL8 ) secretion and alteration of NF-kappaB and AP-1 signalling pathways by Bb were studied by EMSA, confocal microscopy and western blotting
Lee et al., Journal of translational medicine 2009 : Seven out of nine ginsenosides could significantly inhibit TNF-alpha induced CXCL-10 expression in U937 cells and give comparable inhibition of CXCL-10 transcription to those with the extract
Qi et al., J Cell Physiol 2009 : These results suggest that TNF-alpha induces CXCL10 production by activating NF-kappaB through ERK and that IFN-gamma induces CXCL10 production by increasing the activation of STAT1 through JAKs pathways ... IFN-gamma potentiates TNF-alpha induced CXCL10 production in THP-1 cells by increasing the activation of STAT1 and NF-kappaB through JAK1 and JAK2
John et al., J Immunol 2009 (Asthma) : Furthermore, chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and RNA polymerase II to the CXCL8 promoter of asthmatic HASM cells both in the presence and absence of TNF-alpha stimulation
Antonelli et al., Endocr Relat Cancer 2009 (Carcinoma, Papillary...) : The combined effects of interferon gamma (IFNgamma) and tumor necrosis factor alpha (TNFalpha) stimulation on CXCL10 secretion in primary cells from PTCs and TFC were tested ... TNFalpha alone induced a slight but significant CXCL10 secretion only in PTCs ... The stimulation with IFNgamma+TNFalpha induced a synergistic CXCL10 release in both cell types ; however, a secretion more than ten times higher was induced in PTCs. Treatment of TFC with TZDs dose-dependently suppressed IFNgamma+TNFalpha induced CXCL10 release, while TZDs stimulated CXCL10 secretion in PTCs ... In fact, a CXCL10 secretion more than ten times higher has been induced by IFNgamma+TNFalpha in PTCs with respect to TFC
Ichikawa et al., Rheumatol Int 2010 (Arthritis, Rheumatoid) : TNF-alpha induced production of IP-10 , but not IL-15 in cultured synovial cells from RA patients
Földes et al., PloS one 2010 : Expression of downstream TLR signalling pathways was demonstrated in hESC, and IL-1beta, TNFalpha and INFgamma, which bypass the TLRs, stimulated CXCL8 release
Stich et al., Res Vet Sci 2011 : Lipopolysaccharide was a more potent inducer of IL-1ß and CXCL-8 than LTA or PG and LTA is a more potent inducer of CXCL-8 than PG. Based on these data, PAMPs from gram positive and negative bacteria induce TNF , IL-1ß and CXCL-8 production in feline whole blood
Rotondi et al., J Neuroimmunol 2011 : Significant and dose dependent secretions of CXCL10 were induced by IFN-ß but not GA. TNF-a synergistically increased IFN-ß induced CXCL10 secretion
Robins et al., Am J Respir Cell Mol Biol 2011 (Asthma...) : In contrast to epithelial and endothelial cells, TNF-a stimulated CXCL8 synthesis was dependent on ERK1/ERK2 but not on p38 MAPK
Kanda et al., Endocrinology 2011 (Psoriasis) : Visfatin enhanced TNF-a induced CXC chemokine ligand ( CXCL ) 8, CXCL10, and CC chemokine ligand (CCL) 20 secretion and mRNA expression in keratinocytes, although visfatin alone was ineffective
Jornot et al., PloS one 2011 (Inflammation) : Anti-IFN? antibodies and TNF soluble receptor completely blocked CXCL10 upregulation
Alrashdan et al., Am J Physiol Lung Cell Mol Physiol 2012 (Asthma) : Cytomix, IL-1ß, and TNF-a induced CXCL10 mRNA expression more rapidly in asthmatic than nonasthmatic ASM cells ... IL-1ß and/or TNF-a combined with IFN-? synergistically increased asthmatic ASM cell CXCL10 release
Antonelli et al., J Rheumatol 2012 (Scleroderma, Systemic) : In contrast, the synergistic effect of IFN-? and TNF-a on CXCL10 secretion was similar in SSc fibroblasts and in controls
Tannheimer et al., Respir Res 2012 (Inflammation...) : Evaluation of roflumilast ( 1-10 µM ) showed no significant inhibition alone on TGFß1 induced ET-1 and CTGF mRNA transcripts, ET-1 and FN protein production, alpha smooth muscle expression, or TNF-a induced secretion of CXCL10 , CCL5 and GM-CSF
Antonelli et al., Immunobiology 2013 : It has been previously shown IFN-a, -ß, -? and TNF-a ( synergically with IFNs ) dose-dependently induce the release of CXCL9 and CXCL10 chemokines by thyroid follicular cells, suggesting that this process may be related, at least in part, to the appearance of thyroid dysfunction during IFNs therapy
Chang et al., J Allergy Clin Immunol 2012 (Asthma) : In patients with severe asthma, dexamethasone caused less suppression of CCL11 and CXCL8 release induced by TNF-a
Xu et al., Pharmacol Res 2013 : TNF-a induced CXCL8 production by A549 cells : Involvement of the non-neuronal cholinergic system ... In A549 cells, TNF-a increased the release of CXCL8 and ACh and the expression of the subtype 3 MR ( M3R ) ... Furthermore, TNF-a induced CXCL8 secretion was ( i ) inhibited by the MR antagonist tiotropium and the M3R antagonist 4-DAMP and ( ii ) enhanced by the M1/M3R agonist pilocarpine and the cholinesterase inhibitor physostigmine ... Taken as a whole, these results suggest that ACh release by A549 cells enhances TNF-a induced CXCL8 secretion through activation of the M3R ... Our results suggest that the TNF-a induced secretion of CXCL8 in A549 cells is regulated by the release of ACh, the latter 's binding to the M3R and the downstream activation of NF-?B and the ERK1/2 and p38 MAPK signaling pathways
Xu et al., J Immunol 2013 (Psoriasis) : Specific inhibition of miR-31 suppressed NF-?B-driven promoter luciferase activity and the basal and TNF-a induced production of IL-1ß, CXCL1/growth related oncogene-a, CXCL5/epithelial derived neutrophil activating peptide 78, and CXCL8/IL-8 in human primary keratinocytes
Fukui et al., Microbiol Immunol 2013 : Moreover, TLR agonists differentially regulated tumor necrosis factor-alpha induced IL-8 and CXCL10 production by the tested cell types
Bocian et al., J Biol Chem 2013 (Disease Models, Animal...) : Compared with TNF-a , IFN-? treatment induced significantly more CXCL-10, and both factors increased synthesis of CXCL-10 in the presence of decorin
Chen et al., Biochem Biophys Res Commun 2013 (Dermatitis, Atopic...) : LL-37 inhibited the increase of CXCL10 and CCL5 induced by TNF-a- and/or IFN-? but enhanced that of CXCL8
Imaeda et al., Clin Exp Immunol 2013 (Colitis, Ulcerative...) : Furthermore, IL-37b inhibited TNF-a induced interferon-?-inducible protein (IP)-10 expression significantly in human colonic SEMFs
Kobayashi et al., Br J Pharmacol 2013 : Corticosteroid sensitivity was determined by IC50 /EC50 of dexamethasone ( Dex ) on TNF-a induced CXCL8 production in U937 monocytic cell line and peripheral blood mononuclear cells ( PBMC ) from COPD patients
Son et al., Journal of inflammation (London, England) 2013 : Finally, CCL20 and CXCL8 responded synergistically in response to EGF and TNF in OVCAR-3 and SKOV-3 cells
Ohmori et al., J Immunol 1995 : Together these results indicate that the highly synergistic transcriptional activation of the IP-10 gene by IFN-gamma and TNF-alpha involves the cooperation between factors that are independently activated by the two stimuli and that bind to independent sites
Manthey et al., Infect Immun 1993 : Herein, we examined the ability of these structures to regulate murine macrophage tumor necrosis factor (TNF) secretion and LPS-inducible gene expression ( tumor necrosis factor alpha [TNF-alpha ], interleukin-1 beta [IL-1 beta ], IP-10 , type 2 TNF receptor [TNFR-2 ], D3, and D8 genes )
Hu et al., Endocrinology 1998 : Conversely, IP-10 mRNA levels were markedly increased in response to murine interleukin-1alpha, murine tumor necrosis factor-alpha , and murine IFNgamma by 3.3-, 10-, and 26-fold, respectively