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IRAK1 — TNF
Text-mined interactions from Literome
Ferlito et al., J Leukoc Biol 2001
(Leukemia, Monocytic, Acute...) :
However, neither
TNF-alpha nor IL-1beta
induced IRAK degradation or stimulated TNF-alpha or TxB2 production in naive cells
Janssens et al., Mol Cell 2003
:
Furthermore, recent data imply a
role for
IRAK-1 in
tumor necrosis factor receptor (TNFR) superfamily induced signaling pathways as well
Kim et al., J Biol Chem 2005
(Inflammation) :
Importantly, endogenous
mPLK/IRAK was activated in
response to
TNF-alpha or interleukin 1 treatment of primary adipose cells
Rao et al., Mol Cell Biol 2005
(Inflammation) :
Overexpression of
IRAK1c suppressed NF-kappaB activation and
blocked IL-1beta induced IL-6 as well as lipopolysaccharide- and CpG induced
tumor necrosis factor alpha production in multiple cellular systems
Cho et al., J Cell Physiol 2010
(Calcinosis) :
Overexpression of miR-146a induced the inhibition of
IRAK1 expression and inhibited basal and
TNF-alpha- and TLR ligand
induced osteogenic differentiation
Kim et al., Cell Physiol Biochem 2012
(MAP Kinase Signaling System) :
Immunoprecipitation analysis showed that
IRAK1 does not physically interact with TNF receptor 1 (TNFR1) even in the
presence of
TNF-a