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FAS — TNFSF10
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Caspase Cascade in Apoptosis:
TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10)
→
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
(modification, activates)
Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10)
→
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
(modification, activates)
Wang et al., Proc Natl Acad Sci U S A 2001, Garg et al., Indian J Pediatr 1977, Walczak et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Caspase Cascade in Apoptosis:
TRAIL/TRAILR1/FADD complex (TNFRSF10A-FADD-TNFSF10)
→
FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD)
(modification, activates)
Wang et al., Proc Natl Acad Sci U S A 2001, Garg et al., Indian J Pediatr 1977, Walczak et al., EMBO J 1997
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Trauzold et al., Oncogene 2001
(Adenocarcinoma...) :
We report here that the
stimulation of the
CD95- and TRAIL-resistant human pancreatic adenocarcinoma cell line PancTuI with an agonistic anti-CD95 antibody or
TRAIL resulted in activation of protein kinase C and NF-kappaB
Grzaśko et al., Postepy Hig Med Dosw 2004
(Anemia...) :
Expression of
Fas , DR4, and DR5 is
detected on the cell membrane of erythroblasts in all stages, whereas FasL and
TRAIL are present only in more mature erythroblasts
Hofmanová et al., Oncol Rep 2008
(Carcinoma...) :
The two cell lines did not respond to TNF-alpha ( 15 ng/ml ), expressed a limited sensitivity to
anti-Fas antibody ( 200 ng/ml ) and a different
response to
TRAIL ( 100 ng/ml )
Marfè et al., PloS one 2011
(Coronavirus Infections) :
In addition, CCoV-II
induces a remarkable increase in the expression of
TNF related apoptosis inducing ligand ( TRAIL ), while we observed a slight up-regulation of
FasL/Fas at 36 p.i. with a decrease of both proteins at the end of infection