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CTNNB1 — SLC22A3
Text-mined interactions from Literome
Kim et al., Cell Biol Int 2002
:
In normal epithelial cell lines, such as HCE and MDCK cells, that contain functional APC, nuclear
beta-catenin induced by exogenous LEF-1 is rapidly exported and
EMT is not
induced ... Thus, our results demonstrate that LEF-1 can
induce EMT directly when its transcription activity is activated by stable nuclear
beta-catenin ... Normal adult epithelial cells appear to use APC to keep beta-catenin out of the nucleus, thereby avoiding pathologies such as metastases due to
LEF/beta-catenin induced
EMT
Eger et al., Oncogene 2004
(Disease Progression...) :
Induction of
EMT in fully polarized mouse mammary epithelial cells ( EpH4 ) by an inducible c-fos estrogen receptor ( FosER ) oncoprotein
involves loss of E-cadherin expression, nuclear translocation of
beta-catenin , and autocrine production of TGFbeta
Medici et al., Mol Biol Cell 2006
:
However, our results also demonstrate that a complete loss of E-cadherin and transformation to the mesenchymal phenotype are dependent on Smad signaling, which subsequently stimulates formation of
beta-catenin/LEF-1 complexes that
induce EMT
Hsu et al., Cancer Res 2007
(Neoplasm Invasiveness) :
The disruption of
E-cadherin/beta-catenin complex formation
promotes EMT , thereby stimulating tumor progression
Medici et al., Mol Biol Cell 2008
:
Finally, we determined that
beta-catenin-LEF-1 complexes can
promote EMT without upstream signaling pathways
Xie et al., Proc Natl Acad Sci U S A 2010
(Neoplasm Metastasis...) :
Moreover, we showed that DAB2IP functions as a scaffold protein in
regulating EMT by modulating nuclear
beta-catenin/T-cell factor activity
Jiang et al., Zhonghua Nan Ke Xue 2009
(Prostatic Neoplasms) :
E-cadherin and
beta-catenin are differently expressed and distributed in prostate cancer cell lines with different characteristics of epithelial-mesenchymal transition (EMT), and the abnormal activation of the beta-catenin signal pathway may be
involved in the
EMT of prostate cancer cells