◀ Back to HRAS

HRAS — KRAS

Pathways - manually collected, often from reviews:

• NCI Pathway Database PDGFR-beta signaling pathway: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
  Evidence: mutant phenotype
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Reynolds et al., J Biol Chem 2004
  Evidence: assay, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Wright et al., Mol Biol Cell 1997
  Evidence: other species
• NCI Pathway Database IL2-mediated signaling events: RAS family/GDP/Aiolos complex (HRAS_KRAS_HRAS_KRAS_NRAS-IKZF3) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Ebinu et al., Blood 2000*
  Evidence: assay
• NCI Pathway Database PDGFR-beta signaling pathway: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Gibbs et al., J Biol Chem 1990, Benjamin et al., J Biol Chem 1994, Salcini et al., Oncogene 1994, Yokote et al., J Biol Chem 1994
  Evidence: mutant phenotype
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Li et al., Science 1992
  Evidence: assay, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Parry et al., J Immunol 2006, Egan et al., Nature 1993
  Evidence: expresssion pattern, assay, other species
• NCI Pathway Database ErbB2/ErbB3 signaling events: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Goodearl et al., Dev Neurosci 2001
  Evidence: mutant phenotype, assay
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Li et al., Science 1992, Stephens et al., Neuron 1994
  Evidence: assay, other species
• NCI Pathway Database SHP2 signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Rönnstrand et al., Oncogene 1999, Gibbs et al., J Biol Chem 1990, Kundra et al., J Cell Biol 1995, Li et al., Mol Cell Biol 1994
  Evidence: mutant phenotype
• NCI Pathway Database TCR signaling in naïve CD8+ T cells: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Ebinu et al., Blood 2000*
• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
  Evidence: assay
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GTP/Tiam1 complex (HRAS_KRAS_HRAS_KRAS_NRAS-TIAM1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Yamauchi et al., Proc Natl Acad Sci U S A 2005
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database GMCSF-mediated signaling events: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Yang et al., Mol Biol Cell 2006
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database ErbB1 downstream signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Zhao et al., Nat Cell Biol 2007*
  Evidence: assay
• NCI Pathway Database CXCR3-mediated signaling events: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Bonacchi et al., J Biol Chem 2001
  Evidence: assay
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Kouhara et al., Cell 1997
  Evidence: mutant phenotype
• NCI Pathway Database Internalization of ErbB1: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Haugh et al., J Biol Chem 1999
  Evidence: assay
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Qian et al., Neuron 1998
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database EPHB forward signaling: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Elowe et al., Mol Cell Biol 2001
  Evidence: genetic interaction
• NCI Pathway Database PDGFR-beta signaling pathway: RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
  Evidence: assay
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: RAS family/GTP/PI3K complex (PIK3CA-PIK3R1-HRAS_KRAS_HRAS_KRAS_NRAS) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, collaborate)
  Rodriguez-Viciana et al., Nature 1994
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: HRAS → KRAS (reaction)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM RAF1-RAS complex, EGF induced: RAF1-RAS complex, EGF induced complex (RAF1-HRAS-KRAS-NRAS) Garnett et al., Mol Cell 2005
• IRef Corum Interaction: Complex of RAF1-KRAS-HRAS-NRAS (association, anti bait coimmunoprecipitation) Garnett et al., Mol Cell 2005

Text-mined interactions from Literome

Cengel et al., Cancer Biol Ther 2006 (Pancreatic Neoplasms) : Thus, radiosensitization of human cancer cells that express mutated K-RAS occurred under conditions where AZD3409 inihibits the activation of farneyslated H-RAS , but did not inhibit K-RAS activation
Cengel et al., Neoplasia (New York, N.Y.) 2007 (Colorectal Neoplasms...) : Taken together, these findings suggest that EGFR activated H-Ras signaling is initiated by oncogenic K-Ras to promote radiation survival in pancreatic and colorectal cancers
Li et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 1990 (Carcinoma, Hepatocellular...) : However, the mRNA expression of c-Ha-ras , c-N-Ras and c-myc oncogenes was enhanced by 4 mmol/L sodium butyrate treatment, while the expression of c-Ki-ras and c-fos remained unchanged
Li et al., Blood 2011 (Leukemia, Myeloid, Acute...) : We found that endogenous Kras ( G12D ) expression results in markedly elevated Ras protein expression and Ras-GTP levels in Mac1 ( + ) cells, whereas Mx1-Cre, LSL-Nras ( G12D ) mice show much lower Ras protein and Ras-GTP levels
Wang et al., FASEB J 2011 : Dominant negative H-Ras or K-Ras reduced accumulation of H-Ras and K-Ras in focal adhesions induced by IL-1 and also blocked ERK activation and focal adhesion maturation
Quincoces et al., FEBS Lett 1997 : In quiescent NIH3T3 cells transfected with inducible H-ras oncogenes, the induction of H-Ras was followed 12 h later by a 3-fold increase in the mRNA expression of endogenous K-ras and N-ras
Stayrook et al., Anticancer Res 1998 (Pancreatic Neoplasms) : Interestingly, H-Ras , but not K-Ras, farnesylation was inhibited by perillyl alcohol, and perillyl alcohol inhibited MAP kinase phosphorylation in H-ras but not K-ras oncogene transformed pancreatic cells