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PECAM1 — PTPN11

Pathways - manually collected, often from reviews:

• BioCarta cell to cell adhesion signaling: SHP-2 (PTPN11) → PECAM-1(P)/SHP-2 complex (PECAM1-PTPN11) (modification, collaborate)
  
• BioCarta cell to cell adhesion signaling: SHP-2 (PTPN11) → CD31 (PECAM-1) (PECAM1) (modification, collaborate)
• BioCarta cell to cell adhesion signaling: PECAM-1(P)/SHP-2 complex (PECAM1-PTPN11) → CD31 (PECAM-1) (PECAM1) (modification, collaborate)
• Reactome Reaction: PECAM1 → PTPN11 (direct_complex) Jackson et al., J Biol Chem 1997*
• Reactome Reaction: PECAM1 → PTPN11 (reaction) Jackson et al., J Biol Chem 1997*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PTPN11 — PECAM1 (physical association, affinity chromatography technology) Ilan et al., J Biol Chem 2000
• IRef Biogrid Interaction: PTPN11 — PECAM1 (direct interaction, pull down) Jackson et al., J Biol Chem 1997*
• IRef Biogrid Interaction: PTPN11 — PECAM1 (direct interaction, pull down) Pumphrey et al., FEBS Lett 1999*
• IRef Biogrid Interaction: PTPN11 — PECAM1 (direct interaction, pull down) Hua et al., J Biol Chem 1998*
• IRef Biogrid Interaction: PTPN11 — PECAM1 (direct interaction, far western blotting) Pumphrey et al., FEBS Lett 1999*
• IRef Biogrid Interaction: PTPN11 — PECAM1 (physical association, affinity chromatography technology) Hua et al., J Biol Chem 1998*
• IRef Biogrid Interaction: PTPN11 — PECAM1 (physical association, affinity chromatography technology) Jackson et al., J Biol Chem 1997*
• IRef Hprd Interaction: PTPN11 — PECAM1 (in vivo) Jackson et al., J Biol Chem 1997*
• IRef Hprd Interaction: PTPN11 — PECAM1 (in vitro) Jackson et al., J Biol Chem 1997*
• IRef Intact Interaction: PECAM1 — PTPN11 (association, lambda phage display) Cochrane et al., J Mol Biol 2000*
• IRef Intact Interaction: PECAM1 — PTPN11 (association, pull down) Jackson et al., J Biol Chem 1997*
• IRef Intact Interaction: PECAM1 — PTPN11 (association, surface plasmon resonance) Hua et al., J Biol Chem 1998*
• IRef Intact Interaction: PECAM1 — PTPN11 (association, pull down) Hua et al., J Biol Chem 1998*
• IRef Ophid Interaction: PECAM1 — PTPN11 (aggregation, confirmational text mining) Jackson et al., J Biol Chem 1997*
• IRef Ophid Interaction: PECAM1 — PTPN11 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Gratzinger et al., Biochem Biophys Res Commun 2003 : Using differentially phosphorylated recombinant proteins we found that phosphotyrosine 686 preferentially mediates binding and 663 mediates activation of SHP-2 by PECAM-1 ... Thus homophilically engaged, tyrosine phosphorylated PECAM-1 locally activates SHP-2 at cell-cell junctions ; with disruption of the endothelial monolayer, selective dephosphorylation of PECAM-1 leads to redistribution of SHP-2 and pro-migratory changes in phosphorylation of cytoskeletal and focal contact components
Cao et al., J Biol Chem 1998 : In other studies, we demonstrated that phosphorylation of PECAM-1 by Src or Csk family kinases was sufficient to trigger its association with SHP-2