Lin et al., J Cell Sci 2007
:
We also found that ceramide activated protein phosphatase 2A (PP2A) indirectly caused GSK-3beta activation, and that the PP2A regulated PI 3-kinase-Akt pathway was involved in GSK-3beta activation
Qian et al., J Alzheimers Dis 2010
(Alzheimer Disease) :
Inhibition of PP2A with okadaic acid in metabolically active rat brain slices caused inhibition of glycogen synthase kinase-3beta ( GSK-3beta ) via an increase in its phosphorylation at Ser9
Yao et al., Neuroscience 2010
(Memory Disorders) :
ECS also caused tau hyperphosphorylation at multiple Alzheimer related phosphorylation sites with activation of glycogen synthase kinase-3beta ( GSK-3beta ), Akt and phospho-PKR-like endoreticulum ( PERK ), and inhibition of protein phosphatase-2A (PP)-2A