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IL1B — NA
Text-mined interactions from Literome
Parmentier et al., Eur Respir J 2000
:
NAC ( 5 mM ) also
enhanced LPS induced
IL-1beta release from THP-1 cells ( p < 0.001 ) ... In addition, treatment of cells with cycloheximide, an inhibitor of protein synthesis, inhibited the
NAC mediated
IL-1beta release
Mathy-Hartert et al., Osteoarthritis Cartilage 2002
(Osteoarthritis, Knee) :
Interestingly,
NAC increased the
IL-1beta and iNOS mRNA levels but did not significantly modify COX-2 mRNA expression
Kao et al., Clin Exp Pharmacol Physiol 2006
(Body Weight...) :
In addition,
NAC diminished the LPS induced increases in nitrate/nitrite, MG, TNF-a and
IL-1b
Kwon et al., Life Sci 2007
:
IL-1 beta release and caspase-1 activity induced by DSS were significantly
inhibited by a MAPK kinase 1/2 inhibitor, a p38 MAPK inhibitor, and
NAC , however, not by JNK1/2 or a protein kinase C inhibitor
Hu et al., J Toxicol Environ Health 2007
:
The secretion of
IL-1beta and TNF-alpha by silica exposed AM was markedly
inhibited by
NAC and R6G, suggesting that the production of these cytokines is also ROS dependent
Geudens et al., J Heart Lung Transplant 2007
(Disease Models, Animal...) :
NAC administered prior to hilar clamping
led to a significant decrease in macrophages and lymphocytes and interleukin
(IL)-1 beta levels after ischemia ...
NAC also
resulted in significantly fewer macrophages, lymphocytes and neutrophils as well as
IL-1 beta , keratinocyte cytokine ( KC ), monocyte chemoattractant protein (MCP)-1 and IL-6 levels in BAL taken after reperfusion
Liu et al., Mol Biol Rep 2009
(Myocardial Infarction) :
NAC inhibits the pro-inflammatory factors expressions ( TNF-alphaand
IL-1beta ) stimulated by ISO