Feehally et al., Ann Med Interne (Paris) 1999
(Disease Models, Animal...) :
In IgAN pIgA production is reduced in the mucosal immune system, perhaps mediated by a mucosal gamma delta T cell defect, and mucosal IgA responses to immunisation are impaired Phillips et al., J Immunol 1990
:
Because the binding of radiolabeled polymeric IgA (pIgA) to HT-29 cells was inhibited by unlabeled pIgA or a polyclonal anti-SC reagent, but not by IgG, monomeric IgA , or Fab alpha fragments, we conclude that the receptor involved in the increased binding of pIgA is indeed SC