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CDKN1A — NOTCH3
Text-mined interactions from Literome
Noseda et al., Mol Cell Biol 2004
:
Activated
Notch inhibits mitogen induced upregulation of
p21Cip1 and delays cyclin D-cdk4 mediated Rb phosphorylation ...
Notch dependent repression of
p21Cip1 prevents nuclear localization of cyclin D and cdk4
Rooman et al., Am J Pathol 2006
(Metaplasia) :
Chemical inhibition of
Notch signaling
resulted in increased proliferation and induction of the cell-cycle regulator
p21Cip1
Henning et al., Cell Death Differ 2008
:
Induction of the
p21 ( cip/waf ) gene by activated
Notch was mediated by increased binding of p53 to p53 binding sites in the p21 ( cip/waf ) promoter and was independent of the canonical RBP-J binding site
Heo et al., Growth Factors 2008
:
Moreover, TGF-alpha increased cyclin D/CDK 4 and cyclin E/CDK 2 levels, while decreasing
p21cip1/waf1 and p27kip1, which were
blocked by the inhibition of Akt, mTOR and
Notch
Ban et al., Cancer Res 2008
(Sarcoma, Ewing) :
Conversely, forced expression of JAG1, activated
NOTCH3 , or HEY1
induced p53 and
p21 ( WAF1/CIP1 )
Cui et al., Cancer Res 2013
(Neoplasms) :
This upregulation of
Notch3 was
required for the induction of
p21 expression in senescent cells ... Downregulation of Notch3 led to a delayed onset of senescence and extended replicative lifespan, whereas adventitious expression of
Notch3 was
sufficient to activate senescence and
p21 expression ... The ability of Notch3 to induce senescence and
p21 expression was
dependent on the canonical
Notch singling ... The ability of
Notch3 to
induce senescence and
p21 expression was dependent on the canonical Notch singling