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CASP2 — PRDX2

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Herold et al., J Hepatol 2002 (Carcinoma, Hepatocellular...) : TSA increased activation of caspase 3 and expression of cyclin A, p2l ( cip/waf ), bax and ( pro ) -caspase 3, while bcl-2 was downregulated
Papeleu et al., J Hepatol 2003 : TSA upregulated the expression of the anti-apoptotic protein Bcl ( xL ) and did not increase caspase-3-activity and LDH release
Taghiyev et al., Cancer Biol Ther 2005 (Prostatic Neoplasms) : To further investigate the role of caspase-9 in TSA mediated apoptosis we used two different approaches : ( 1 ) cells were pretreated with the caspase-9 inhibitor Z-LEHD-fmk, and ( 2 ) cells were transfected with a dominant negative form of caspase-9
Camelo et al., J Neuroimmunol 2005 (Disease Models, Animal...) : TSA also inhibits caspase activation and down-regulates gene targets of the pro-apoptotic E2F transcription factor pathway
Choi et al., Int J Oncol 2005 (Carcinoma, Non-Small-Cell Lung...) : TSA treatment induced the proteolytic activation of caspase-3 and caspase-9, and a concomitant degradation of poly ( ADP-ribose ) -polymerase protein
Fandy et al., Neoplasia (New York, N.Y.) 2005 (Multiple Myeloma) : The cytotoxic effect of both SAHA and TSA was caspase- and calpain independent
Woo et al., Exp Mol Pathol 2007 (Leukemia) : TSA treatment inhibited the levels of cIAP family members and induced the proteolytic activation of caspase-3 , which was associated with concomitant degradation of poly ( ADP-ribose ) -polymerase and beta-catenin protein
Kwon et al., Carcinogenesis 2006 (Cell Transformation, Neoplastic...) : On the other hand, together with TUNEL ( terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ) assay, activations of caspase-8 and caspase-3 by TSA and ProI were noticed, suggesting the involvement of apoptotic process in chemosensitization of 267B1/K-ras cells
Kim et al., Exp Mol Med 2006 (Lung Neoplasms) : Catalytic activation of caspase-3 by TSA was further confirmed by cleavage of pro-caspase-3 and intracellular substrates, including poly ( ADP-ribose ) polymerase ( PARP ) and inhibitor of caspase activated deoxyribonuclease ( ICAD )
Dalgard et al., Clin Cancer Res 2008 (Retinal Neoplasms...) : TSA and MS-275 increased caspase-3/7 activity
Dubois et al., Mol Biochem Parasitol 2009 : Moreover, TSA caused an increase in apoptosis in schistosomula shown by the TUNEL assay and an increase in caspase 3/7 activity
Shiau et al., Eur J Nutr 2010 (Carcinoma, Non-Small-Cell Lung) : Genistein significantly enhanced TSA induced caspase-3 activity in A549 cells by 34 % at 24 h, and the caspase-3 inhibitor partly inhibited the enhancing effect of genistein on TSA induced apoptosis ... beta-Carotene did not significantly affect TSA induced caspase-3 activity
Yoshikawa et al., Eur J Pharmacol 2010 (MAP Kinase Signaling System) : TSA prevented TGF-beta1 induced apoptosis and the activation of caspase-8 and caspase-9 in RPTECs but did not inhibit the TGF-beta1 induced phosphorylation of Smad3 and p38 mitogen activated protein kinase ( MAPK )
Kim et al., Mol Cancer Ther 2010 (Carcinoma, Squamous Cell...) : Mechanistically, we found that TSA increased PS-341 induced Noxa expression and caspase activation in HNSCC cells