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ESR1 — XBP1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: ESR1 → XBP1 (increases, XBP1 Activity, ESR1 Activity) Fang et al., Biochem Biophys Res Commun 2004*
  Evidence: These data identify a novel function of XBP-1 and suggest that regulation of large-scale chromatin unfolding by XBP-1 may be responsible for the enhancement of ERalpha transcriptional activity.
• NCI Pathway Database FOXA1 transcription factor network: E2/ERA complex (ESR1) → XBP1 (XBP1) (transcription, activates) Carroll et al., Cell 2005
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: ESR1 — XBP1 (direct interaction, pull down) Ding et al., Nucleic Acids Res 2003*
• IRef Biogrid Interaction: ESR1 — XBP1 (physical association, affinity chromatography technology) Ding et al., Nucleic Acids Res 2003*
• IRef Hprd Interaction: XBP1 — ESR1 (in vitro) Ding et al., Nucleic Acids Res 2003*
• IRef Hprd Interaction: XBP1 — ESR1 (in vivo) Ding et al., Nucleic Acids Res 2003*
• IRef Ophid Interaction: XBP1 — ESR1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Ding et al., Nucleic Acids Res 2003 : However, the role of XBP-1 in ERalpha signaling remains to be elucidated ... The maximal effects of XBP-1S and XBP-1U on ERalpha transactivation were observed when they were co-expressed with full-length ERalpha ... The bZIP deleted mutants of XBP-1S and XBP-1U completely abolished ERalpha transactivation by XBP-1S and XBP-1U
Ding et al., Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 2003 : To determine the effects of XBP-1S and XBP-1U on the transcriptional activity of ERalpha , MDA-MB-231 breast cancer cells were cotransfected with the expression vectors for ERalpha and either pcDNA3-FLAG-XBP-1S or pcDNA3-FLAG-XBP-1U
Fang et al., Biochem Biophys Res Commun 2004 : XBP-1 increases ERalpha transcriptional activity through regulation of large-scale chromatin unfolding ... However, how XBP-1S and XBP-1U regulate ERalpha transcriptional activity remains unknown ... Wild-type XBP-1S and XBP-1U, but not the mutants that completely abolished the ERalpha transcriptional activation, increased the chromatin unfolding activity of ERalpha
Ding et al., Yi Chuan Xue Bao 2004 (Breast Neoplasms) : However, little is known about the expression pattern of XBP-1S and XBP-1U in breast cancer cells and about their roles in ERalpha signaling ... Estrogen response element ( ERE ) -containing luciferase reporter assay was used to determine the effects of XBP-1S and XBP-1U on the transcription activity of ERalpha in MDA-MB-435 breast cancer cells ... The result showed that both XBP-1S and XBP-1U enhanced the transcription activity of ERalpha in a hormone independent and dose dependent manner and the activity of of XBP-1S is higher than that of XBP-1U