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BDNF — PPP1R1B

Text-mined interactions from Literome

Petersén A et al., Brain Res Bull 2001 (Huntington Disease) : We confirmed that BDNF enhances survival and DARPP-32 expression in primary striatal cultures derived from postnatal mice
Stroppolo et al., J Neurochem 2001 : Role of phosphatidylinositide 3-kinase in brain derived neurotrophic factor induced DARPP-32 expression in medium size spiny neurons in vitro ... We investigated the intracellular signal transduction pathways activated by BDNF in MSNs and via which BDNF induces DARPP-32 expression
Bogush et al., J Biol Chem 2007 (Huntington Disease) : DARPP-32 induction by BDNF in vitro requires phosphatidylinositide 3-kinase (PI3K), but inhibition of phosphorylation of protein kinase B/Akt does not entirely abolish expression of DARPP-32 ... Using pharmacologic inhibitors of PI3K, Akt, and cyclin dependent kinase 5 (cdk5) and constitutively active and dominant negative PI3K, Akt, cdk5, and p35 viruses in cultured striatal neurons, we measured BDNF induced levels of DARPP-32 protein and/or mRNA ... We demonstrated that both the PI3K/Akt/mammalian target of rapamycin and the cdk5/p35 signal transduction pathways contribute to the induction of DARPP-32 protein levels by BDNF and that the effects are on both the transcriptional and translational levels
Pedrini et al., J Neurochem 2008 : Thus, the signal transduction pathways mediated by RA are very different than those mediating DARPP-32 induction by brain derived neurotrophic factor
Ivkovic et al., Neuroscience 1997 : These data suggest that brain derived neurotrophic factor directly or indirectly regulates DARPP-32 transcription in medium spiny neurons