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MYC — RPL11

Pathways - manually collected, often from reviews:

• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5) → MYC/Max/RPL11 complex (MYC-MAX-RPL11) (transcription, activates)
  Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/RPL11 complex (MYC-MAX-RPL11) → nucleus (EP300/CREBBP) (transcription, inhibits) Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/RPL11 complex (MYC-MAX-RPL11) → Nucleolin (NCL) (transcription, inhibits) Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/RPL11 complex (MYC-MAX-RPL11) → RPL11 (RPL11) (modification, collaborate) Dai et al., EMBO J 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/RPL11 complex (MYC-MAX-RPL11) → MYC/Max complex (MYC-MAX) (modification, collaborate) Dai et al., EMBO J 2007
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: RPL11 (RPL11) → MYC/Max complex (MYC-MAX) (modification, collaborate) Dai et al., EMBO J 2007
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MYC — RPL11 (physical association, affinity chromatography technology) Dai et al., EMBO J 2007
• IRef Intact Interaction: MYC — RPL11 (physical association, anti tag coimmunoprecipitation) Dai et al., EMBO J 2007

Text-mined interactions from Literome

Dai et al., Cell cycle (Georgetown, Tex.) 2007 : Feedback regulation of c-Myc by ribosomal protein L11
Dai et al., J Biol Chem 2010 : We previously found that ribosomal protein L11 inhibits c-Myc activity by blocking the recruitment of its co-activator transformation/transcription domain associated protein ( TRRAP ) to the promoter regions of c-Myc target genes that are transcribed by RNA polymerases I and II