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ADCY8 — LPA

Text-mined interactions from Literome

van der Bend et al., EMBO J 1992 : Exogenous LPA stimulates GTP dependent phosphoinositide hydrolysis and inhibits adenylate cyclase in its target cells, but the site of action of LPA is unknown
Avendaño-Vázquez et al., Biochem J 2005 (Calcium Signaling) : In C9 cells, LPA ( lysophosphatidic acid ) induced inositol phosphate production, increased intracellular calcium concentration and inhibited adenylate cyclase activity
Jalink et al., Cell Growth Differ 1993 : LPA stimulates phospholipase C and inhibits adenylate cyclase in its target cells, apparently by activating a specific G-protein coupled receptor
Arimura et al., Life Sci 1998 : An EGF receptor mediated signal attenuates the inhibitory effect of LPA on an adenylate cyclase activity ... When an effect of lysophosphatidic acid (LPA) stimulation on an adenylate cyclase activity was examined, LPA partly attenuated forskolin stimulated adenylate cyclase activity via Gi because IAP pretreatment blocked the inhibitory effect of LPA ... Pretreatment with EGF reduced the ability of LPA to inhibit the forskolin stimulated adenylate cyclase activity, while the pretreatment did not have any effects on the forskolin stimulated activity