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IL12B — SOAT1

Text-mined interactions from Literome

Sugawara et al., Tohoku J Exp Med 2004 (Genetic Predisposition to Disease...) : Therefore, STAT1 regulates IL-12 expression and appears to be a critical transcription factor in controling mycobacterial infection
Muthian et al., J Clin Immunol 2004 (Disease Models, Animal...) : In vitro treatment of activated T cells with quercetin blocks IL-12 induced tyrosine phosphorylation of JAK2, TYK2, STAT3 , and STAT4, resulting in a decrease in IL-12 induced T cell proliferation and Th1 differentiation
Walker et al., Arch Virol Suppl 2005 (Ehrlichiosis) : Ehrlichiae attach to L-selectin and E-selectin, inhibit phagolysosomal fusion, apoptosis, and JAK/STAT activation, and downregulate IL-12 , IL-15, IL-18, TLR2 and 3, and CD14
Muthian et al., J Neurosci Res 2006 (Disease Models, Animal...) : Treatment of activated T cells with 1,25 ( OH ) 2D3 also inhibited the IL-12 induced tyrosine phosphorylation of JAK2, TYK2, STAT3 , and STAT4 in association with a decrease in T cell proliferation in vitro
Berenson et al., J Immunol 2006 : In the present study, we compared the capacity of IL-12 and IFN-alpha to induce Th1 differentiation, STAT4 phosphorylation, and IFN-gamma production in murine T cells
Sonobe et al., Biochem Biophys Res Commun 2008 : Additionally, microglia expressed a functional receptor for IL-23, as IL-23 enhanced the Interferon (IFN)-gamma induced signal transducer and activator of transcription ( STAT ) 1 phosphorylation and chemokine production
Yu et al., Biochem Pharmacol 2008 : Like quercetin inhibits macrophage induced cytokine production, it also blocks IL-12 dependent JAK-STAT signaling in Th cells
Wang et al., Blood 2008 (MAP Kinase Signaling System) : IL-12 and IL-18 stimulated autoreactively activated NKT cells to secrete IFN-gamma, and this was mediated by Janus kinase-signal transducers and activators of transcription ( JAK-STAT ) -dependent signaling without induction of calcium flux
Stewart et al., Cancer Cell 2009 (Neoplasms) : In this issue of Cancer Cell, Kortylewski et al. show that in the tumor microenvironment, STAT3 enhances the expression of the protumor cytokine IL-23 in macrophages but inhibits the antitumor cytokine IL-12 in dendritic cells ... In this issue of Cancer Cell, Kortylewski et al. show that in the tumor microenvironment, STAT3 enhances the expression of the protumor cytokine IL-23 in macrophages but inhibits the antitumor cytokine IL-12 in dendritic cells
Cho et al., J Immunol 1996 : Thus, STAT4 activation was not IL-12 specific, and IL-12 and IFN-alpha activated STAT4 through both tyrosine and serine phosphorylation
Bright et al., J Immunol 1998 : TGF-beta inhibits IL-12 induced activation of Jak-STAT pathway in T lymphocytes