◀ Back to E2F1
E2F1 — IRF3
Text-mined interactions from Literome
Xu et al., Mol Biol Rep 2010
:
Characterization of the human
IRF-3 promoter and its
regulation by the transcription factor
E2F1
Xu et al., Immunogenetics 2011
:
Here we report that the transcription factor
E2F1 negatively
regulates the basal transcriptional activity of
IRF-3 and deregulates IRF-3 expression at mRNA level ... Overexpression of E2F1, but not a mutant
E2F1 ,
represses the
IRF-3 promoter activity in reporter gene assays while knocking down of endogenous E2F1 by shRNA strategy results in enhanced IRF-3 promoter activity ... These results suggest that
E2F1 negatively
regulates IRF-3 transcription through binding to the E2F consensus binding site