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PRKACB — PTGS2
Text-mined interactions from Literome
Zhou et al., J Clin Endocrinol Metab 1999
:
Inhibition of
PKA activity by cotreatment with isoquinoline-sulfonamide ( H-89 )
prevented hCG from increasing
COX-2 protein levels
Tamura et al., J Clin Endocrinol Metab 2002
:
COX-2 mRNA, protein, and PGE ( 2 ) levels in IL-1beta treated ESC were decreased by a PKA inhibitor, a nuclear factor ( NF-kappaB ) inhibitor, and an ERK1/2 inhibitor, but not by a p38 MAPK inhibitor or a PKC inhibitor, suggesting the possible
involvement of
PKA , NF-kappaB, and/or the ERK1/2 signaling pathway ( s ) in IL-1beta mediated
COX-2 gene induction in ESC
Tortora et al., Clin Cancer Res 2003
(Neovascularization, Pathologic) :
COX-2 expression can be induced by EGFR activation and is
regulated by cAMP and
PKA
Sakuma et al., Bone 2004
:
Treatment with specific inhibitors indicated that PGE ( 2 ), EP2A, and EP4A
induced COX-2 expression largely through
protein kinase A (PKA)
Choudhary et al., Biochem Biophys Res Commun 2004
:
In contrast,
PKA inhibitors, used at doses that inhibited forskolin stimulated luciferase activity by 90 %,
reduced [ Ca(+2) ] ( e ) -stimulated
COX-2 mRNA expression and promoter activity by 80-90 %
Park et al., Biochem Biophys Res Commun 2007
:
PKA , ERK, and p38 MAPK pathways
regulate COX-2 mRNA expression induced by rolipram, in which PKA is a central regulator of the ERK and p38 MAPK pathways
Simeone et al., Int J Oncol 2007
(Breast Neoplasms...) :
Protein kinase A (PKA) and protein kinase C ( PKC ) are
activated by
COX-2 and are involved in IL-8 regulation
Misior et al., Am J Respir Cell Mol Biol 2009
:
Recent studies have suggested that GCs render agents of inflammation such as IL-1 beta and TNF-alpha mitogenic to ASM, via suppression of ( antimitogenic ) induced
cyclooxygenase-2 dependent
PKA activity
Friis et al., J Am Soc Nephrol 2009
:
Taken together, our results show that a 5 to 7 % decrease in extracellular tonicity leads to AQP1 mediated water influx in JG cells,
PLA(2)/COX-2 mediated prostaglandin dependent formation of cAMP, and
activation of
PKA , which promotes exocytosis of renin
Lee et al., Allergy, asthma & immunology research 2013
:
LPS induced
COX-2 expression in RAW 264.7 macrophages was enhanced by exogenous PGE2 or cyclic AMP ( cAMP ) analogue and was
suppressed by a COX inhibitor ( indomethacin ), a
protein kinase A (PKA) inhibitor ( KT5720 ), and A kinase anchoring protein ( AKAP ) disruptors ( Ht31 and RIAD )
Warnock et al., J Cell Physiol 1995
(Second Messenger Systems) :
The addition of various PKC inhibitors also blocked the IL-1 beta induction of PGHS-2 mRNA but did not alter PGHS-1 mRNA expression ; inhibitors of
protein kinase A (PKA) or tyrosine kinase ( TK )
had only a limited effect on IL-1 beta induced
PGHS-2 mRNA expression
Tsai et al., Endocrinology 1996
:
PGHS-2 was acutely ( < 12 h )
increased by
PKA , and to a lesser extent by PKC ... Temporal expression of FP receptor mRNA is not consistent with the involvement of FP receptor in ovulation and suggests that
PKA stimulates
PGHS-2 and FP receptor mRNA by distinct mechanisms