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FGF1 — MMP9

Text-mined interactions from Literome

Lungu et al., Mol Carcinog 2008 (Mammary Neoplasms, Experimental) : Here, we investigate the effect of fibroblast growth factor-1 (FGF-1) on the expression of MMP-9 in ENU1564, an ethyl-N-nitrosourea induced rat mammary adenocarcinoma cell line ... To gain insight into the molecular mechanism of MMP-9 regulation by FGF-1 , we investigated the role of components of PI3K-Akt and MEK1/2-ERK signaling pathways in our system since NF-kappaB and AP-1 transcription factor binding sites have been characterized in the upstream region of the MMP-9 gene ... Taken together, these results demonstrated that FGF-1 induced MMP-9 expression in ENU1564 cells is associated with increasing DNA binding activities of NF-kappaB and AP-1 and involve activation of a dual signaling pathway, PI3K-Akt and MEK1/2-ERK
Hajitou et al., Oncogene 1998 (Cell Transformation, Neoplastic...) : Interestingly, FGF-3 production greatly stimulated the synthesis of pro-MMP-9 ( Matrix Metalloprotease-9 ) and, to a lesser extent, that of pro-MMP-2