Gene interactions and pathways from curated databases and text-mining

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F2 — PDGFA

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: PDGFA → F2 (increases, F2 Translocation, PDGFA Activity) Heldin et al., Physiol Rev 1999
    Evidence: For PDGF to affect wound healing in vivo it has to be present at the site of the wound. Early observations revealed that PDGF is released by platelets and secreted by activated macrophages (424), thrombin-stimulated endothelial cells (169), smooth muscle cells of damaged arteries (486), activated fibroblasts (348), as well as by epidermal keratinocytes (16), suggesting that PDGF is present in the wounded area.