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PIN1 — TP53

Pathways - manually collected, often from reviews:

• NCI Pathway Database p53 pathway: p53 (TP53) → p53/PIN1 complex (TP53-PIN1) (proteasomal ubiquitin-dependent protein catabolic process, collaborate)
  Rodriguez et al., Mol Cell Biol 2000, Mayo et al., Proc Natl Acad Sci U S A 2001, Zhou et al., Nat Cell Biol 2001, Li et al., Science 2003, Ferreon et al., Proc Natl Acad Sci U S A 2009, Siepe et al., Nat Cell Biol 2009, Haupt et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database p53 pathway: p53/PIN1 complex (TP53-PIN1) → MDM2/UBCH5/Cbp/p300 complex (MDM2-UBE2D1-EP300_CREBBP) (proteasomal ubiquitin-dependent protein catabolic process, inhibits)
  Rodriguez et al., Mol Cell Biol 2000, Mayo et al., Proc Natl Acad Sci U S A 2001, Zhou et al., Nat Cell Biol 2001, Li et al., Science 2003, Ferreon et al., Proc Natl Acad Sci U S A 2009, Siepe et al., Nat Cell Biol 2009, Haupt et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database p53 pathway: p53 (TP53) → PIN1 (PIN1) (modification, collaborate) Zheng et al., Nature 2002*, Zacchi et al., Nature 2002*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database p53 pathway: p53 (TP53) → p53/PIN1 complex (TP53-PIN1) (modification, collaborate)
  Zheng et al., Nature 2002*, Zacchi et al., Nature 2002*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database p53 pathway: PIN1 (PIN1) → p53/PIN1 complex (TP53-PIN1) (modification, collaborate)
  Zheng et al., Nature 2002*, Zacchi et al., Nature 2002*
  Evidence: mutant phenotype, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PIN1 — TP53 (physical association, affinity chromatography technology) Wulf et al., J Biol Chem 2002*
• IRef Biogrid Interaction: PIN1 — TP53 (direct interaction, pull down) Wulf et al., J Biol Chem 2002*
• IRef Biogrid Interaction: PIN1 — TP53 (physical association, affinity chromatography technology) Zacchi et al., Nature 2002*
• IRef Biogrid Interaction: PIN1 — TP53 (direct interaction, pull down) Zacchi et al., Nature 2002*
• IRef Biogrid Interaction: PIN1 — TP53 (direct interaction, two hybrid) Vinayagam et al., Science signaling 2011
• IRef Hprd Interaction: TP53 — PIN1 (in vitro) Wulf et al., J Biol Chem 2002*, Zheng et al., Nature 2002*, Zacchi et al., Nature 2002*
• IRef Hprd Interaction: TP53 — PIN1 (in vivo) Wulf et al., J Biol Chem 2002*, Zheng et al., Nature 2002*, Zacchi et al., Nature 2002*
• IRef Intact Interaction: PIN1 — TP53 (physical association, pull down) Zheng et al., Nature 2002*
• IRef Intact Interaction: PIN1 — TP53 (physical association, pull down) Mantovani et al., Nature structural & molecular biology 2007*
• IRef Intact Interaction: PIN1 — TP53 (physical association, coimmunoprecipitation) Zacchi et al., Nature 2002*
• IRef Intact Interaction: PIN1 — TP53 (physical association, anti bait coimmunoprecipitation) Girardini et al., Cancer Cell 2011*
• IRef Intact Interaction: PIN1 — TP53 (physical association, anti tag coimmunoprecipitation) Girardini et al., Cancer Cell 2011*
• IRef Intact Interaction: PIN1 — TP53 (physical association, two hybrid) Vinayagam et al., Science signaling 2011
• IRef Intact Interaction: PIN1 — TP53 (physical association, pull down) Girardini et al., Cancer Cell 2011*
• IRef Intact Interaction: PIN1 — TP53 (physical association, pull down) Zacchi et al., Nature 2002*
• IRef Ophid Interaction: PIN1 — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Wulf et al., J Biol Chem 2002 : Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage ... Furthermore, Pin1 regulates the stability of p53 and its transcriptional activity toward the p21 promoter
Zheng et al., Nature 2002 : The Pin1 mediated p53 activation requires the WW domain, a phosphorylated Ser/Thr-Pro motif interaction module, and the isomerase activity of Pin1
Haupt et al., Cell cycle (Georgetown, Tex.) 2004 (Cell Transformation, Neoplastic) : An intriguing player in this process is the prolyl isomerase Pin1 , which induces a conformational change in p53 , and more recently identified, also in p73, in response to DNA damage
Berger et al., Mol Cell Biol 2005 (Osteosarcoma) : Our study unravels the pathway by which Pin1 activates p53 in response to DNA damage and explains how Pin1 protects p53 from Mdm2
Takahashi et al., Oncogene 2007 (Thymus Hyperplasia) : Pin1 is required for the timely activation of p53 , resulting in apoptosis or cell cycle arrest
Cohen et al., Biochimie 2008 : In contrast to observations made in other cells, in CTB, interaction of Pin1 and p53 does not involve phosphorylation of residues ser33, thr81 and ser315 of p53 ; on the contrary, phosphorylation of p53 leads to the rapid disappearance of some HMWC and destabilises p53