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PLD5 — PTH
Text-mined interactions from Literome
Singh et al., J Bone Miner Res 2003
:
Regulation of
parathyroid hormone stimulated
phospholipase D in UMR-106 cells by calcium, MAP kinase, and small G proteins ...
PTH activated p42/p44 MAP kinase, and the effects of PTH, PDBu, and ionomycin on
PLD , but not on calcium influx, were
prevented by the MEK inhibitors PD98059 and U0126 ... Small G proteins were shown to be involved in the
effects of
PTH , PDBu, and ionomycin on
PLD
Radeff et al., Cell Signal 2004
(Bone Resorption) :
Role of protein kinase A, phospholipase C and
phospholipase D in
parathyroid hormone receptor regulation of protein kinase Calpha and interleukin-6 in UMR-106 osteoblastic cells
Radeff et al., J Bone Miner Res 2004
:
Diacylglycerol ( DAG ) generation from phospholipase D ( PLD ) is one pathway of PKC activation, and
PTH mediated
PLD activity is dependent on small G-proteins of the Rho family
Singh et al., Endocrinology 2005
:
In the current study, we investigated the role of heterotrimeric G proteins in mediating
PTH stimulated
PLD activity in UMR-106 osteoblastic cells
Garrido et al., Mol Endocrinol 2009
:
Role of
phospholipase D in
parathyroid hormone type 1 receptor signaling and trafficking ...
PTH ( 1-34 )
increased total
PLD activity by 3-fold in CHO-R3 cells and by 2-fold in ROS cells ... However, only WT-PLD2 expression increased
PTH dependent
PLD activity in ROS cells
Singh et al., Endocrinology 1999
:
The results suggest that in the UMR-106 cell line
PTH can
stimulate activation of
PLD by a mechanism other than through protein kinase C
Friedman et al., Endocrinology 1999
:
PTH did, however,
activate phospholipase D with attendant formation of diacylglycerol in distal cells