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IRF6 — ODC1
Text-mined interactions from Literome
Endo et al., Br J Pharmacol 1992
(Drug-Induced Liver Injury) :
2. The
induction of
ODC by
LPS , IL-1 or TNF was suppressed by GalN in the liver, and this suppression preceded the hepatic congestion ... 4.
LPS-pretreatment before injection of LPS plus GalN
prevented the suppression of
ODC activity and prevented the hepatic congestion and death
Seong et al., J Microbiol 2009
(Salmonella Infections) :
ODC expression was
increased by bacteria or
LPS and repressed by inhibitors against mitogen activated protein kinases ( MAPKs ) in Toll-like receptor 4 (TLR4) signaling pathway
Taffet et al., J Cell Physiol 1985
(Neoplasms, Experimental) :
Ornithine decarboxylase ( ODC, EC 4.1.1.17 ) activity is
induced in the RAW264 macrophage-like cell line by bacterial
lipopolysaccharide (LPS) ... As little as 0.1 ng/ml
LPS promoted an increase in
ODC activity, while maximal ODC activity ( 30-fold above control ) was induced with 1.0 microgram/ml LPS ... The
LPS induced increase in
ODC activity was prevented by inhibitors of protein and RNA synthesis ... However, PGE2 ( 1 microgram/ml ) and 8-bromo-cyclic AMP ( 1 mM ), neither of which had an effect on ODC activity when added alone, each acted synergistically to enhance the
LPS induction of
ODC activity ... The extent of the increase in
ODC in
response to
LPS increased with increasing cellular density
Prosser et al., Arch Biochem Biophys 1988
:
Lipopolysaccharide (LPS) activation of macrophages
resulted in a maximal
ODC response after 6 to 9 h with a 10- to 12-fold elevation in enzyme activity ... This elevation in ODC appeared to be regulated by PGE2 since indomethacin inhibited
LPS induced macrophage
ODC levels by 70 %
Greenfield et al., In Vitro 1984
:
Lipopolysaccharide (LPS) , the active component of bacterial endotoxin,
caused no significant increase in
ornithine decarboxylase (ODC) activity in serum starved, Chinese hamster ovary fibroblasts
Endo et al., Biochem Pharmacol 1984
:
ODC induction by
LPS in C3H/HeJ mice, the lymphocytes and/or macrophages of which are known to be less responsive to LPS, was much less than in C3H/He and ddI mice ...
ODC induction by
LPS was suppressed by dexamethasone and cycloheximide ... Actinomycin D did not suppress
ODC induction by
LPS but, rather, enhanced it ... These results suggest that ( 1 ) lymphocytes and/or macrophages may participate in the
induction of
ODC by mitogenic substances as well as by
LPS , ( 2 ) ODC may be induced by mitogenic substances without the synthesis of RNA, and ( 3 ) the translation of existing RNA may be accelerated by actinomycin D
Matsuzaki et al., J Hepatol 1997
(Shock, Septic) :
The levels of
LPS induced
ODC activity, the putrescine ( PUT ) and N1-acetylspermidine ( A-SPD ) were reduced by the administration of PGE1 ... Corticosterone and AA-2414 treatment may attenuate the LPS induced production of eicosanoids, and enhance the
LPS induced
ODC activation