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AXIN1 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
TP53
—
AXIN1
(physical association, affinity chromatography technology)
-
IRef Biogrid Interaction:
TP53
—
AXIN1
(physical association, affinity chromatography technology)
Li et al., Oncogene 2011*
-
MIPS CORUM DAXX-Axin-p53-HIPK2 complex:
DAXX-Axin-p53-HIPK2 complex complex (AXIN1-DAXX-HIPK2-TP53)
Li et al., Cancer Res 2007*
-
MIPS CORUM Axin-p53-HIPK2 complex:
Axin-p53-HIPK2 complex complex (AXIN1-HIPK2-TP53)
Rui et al., EMBO J 2004*
-
MIPS CORUM Daxx-Axin-p53 complex:
Daxx-Axin-p53 complex complex (AXIN1-DAXX-TP53)
Li et al., Cancer Res 2007*
-
IRef Corum Interaction:
Complex of HIPK2-TP53-AXIN1
(association, anti bait coimmunoprecipitation)
Rui et al., EMBO J 2004*
-
IRef Corum Interaction:
Complex of AXIN1-DAXX-TP53
(association, anti tag coimmunoprecipitation)
Li et al., Cancer Res 2007*
-
IRef Corum Interaction:
Complex of TP53-AXIN1-HIPK2-DAXX
(association, anti bait coimmunoprecipitation)
Li et al., Cancer Res 2007*
-
IRef Intact Interaction:
TP53
—
AXIN1
(physical association, anti bait coimmunoprecipitation)
Li et al., Oncogene 2011*
-
IRef Intact Interaction:
Complex of AXIN1-TP53-AXIN1-HIPK2-HIPK2-TP53
(physical association, anti tag coimmunoprecipitation)
Li et al., Oncogene 2011*
-
IRef Intact Interaction:
Complex of AXIN1-TP53
(physical association, anti bait coimmunoprecipitation)
Li et al., Oncogene 2011*
Text-mined interactions from Literome
Rui et al., EMBO J 2004
:
Axin , but not AxindeltaHIPK2,
activates HIPK2 mediated
p53 phosphorylation at Ser 46, facilitating p53 dependent transcriptional activity and apoptosis
Frappart et al., EMBO J 2007
(Medulloblastoma) :
These neurological defects arose from DNA damage as Brca2 ( LoxP/LoxP ) ; Nestin-cre mice showed extensive
gammaH2AX in neural tissue and
p53 deficiency
restored brain histology but lead to rapid formation of medulloblastoma brain tumors
Li et al., Oncogene 2011
:
Moreover, we found that dominant negative mutants of PML blocked
AXIN induced
p53 activation, and that AXIN promotes PML sumoylation, a modification necessary for PML functions
Atsumi et al., PloS one 2011
(Genomic Instability...) :
Onset of quiescence following
p53 mediated down-regulation of
H2AX in normal cells
Lu et al., Oncol Rep 2013
(Glioma) :
In addition, ectopic expression of Axin by transient transfection of C6 cells with rAxin revealed that overexpression of
Axin induced cell cycle arrest and apoptosis with an upregulation of
p53