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Stoica et al., Mol Cell Neurosci 2003
:
We show that ceramide treatment initiates a cascade of biochemical alterations associated with cell death : earliest signal transduction changes involve Akt dephosphorylation and inactivation followed by dephosphorylation of proapoptotic regulators such as BAD ( proapoptotic Bcl-2 family member ), Forkhead family transcription factors, glycogen synthase kinase 3-beta, mitochondrial depolarization and permeabilization, release of cytochrome c into the cytosol, and caspase-3 activation
Takadera et al., Cell Mol Neurobiol 2010
:
Moreover, caspase-3 activation was inhibited by glycogen synthase kinase-3 inhibitors