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CDT1 — MCM6

Pathways - manually collected, often from reviews:

• BioCarta cdk regulation of dna replication: ORC/CDC6/CDT1/Mcm2-7/SCF complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-KITLG) → ORC/CDC6/CDT1/Mcm2-7 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7) (modification, collaborate)
  
• BioCarta cdk regulation of dna replication: ORC/CDC6/CDT1/Mcm2-7/SCF complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-KITLG) → KITL (KITLG) (modification, collaborate)
• BioCarta cdk regulation of dna replication: ORC/CDC6/CDT1/Mcm2-7 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7) → KITL (KITLG) (modification, collaborate)
• BioCarta cdk regulation of dna replication: ORC/CDC6/CDT1/Mcm2-7 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7) → Mcm2-7 complex (MCM2-MCM3-MCM4-MCM5-MCM6-MCM7) (modification, collaborate)
  
• BioCarta cdk regulation of dna replication: ORC/CDC6/CDT1/Mcm2-7 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7) → ORC/CDC6/CDT1 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1) (modification, collaborate)
  
• BioCarta cdk regulation of dna replication: Mcm2-7 complex (MCM2-MCM3-MCM4-MCM5-MCM6-MCM7) → ORC/CDC6/CDT1 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1) (modification, collaborate)
  
• BioCarta cdk regulation of dna replication: ORC/CDC6/CDT1/Mcm2-7/SCF complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-KITLG) → ORC/CDC6/CDT1/Cyclin E/CDK2/p27 complex (ORC1L-ORC2L-ORC3L-ORC4L-ORC5L-ORC6L-CDC6-CDT1-CCNE1-CDK2-CDKN1B) (regulation of DNA replication initiation, activates)
  
• Reactome Reaction: CDT1 → MCM6 (indirect_complex) Herbig et al., Mol Biol Cell 1999
• Reactome Reaction: CDT1 → MCM6 (reaction) Herbig et al., Mol Biol Cell 1999, Bell et al., Annu Rev Biochem 2002

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CDT1 — MCM6 (physical association, affinity chromatography technology) Sugimoto et al., Mol Biol Cell 2008
• IRef Biogrid Interaction: CDT1 — MCM6 (physical association, affinity chromatography technology) Teer et al., J Biol Chem 2008*
• IRef Biogrid Interaction: CDT1 — MCM6 (association, x-ray crystallography) Liu et al., Nucleic Acids Res 2012*
• IRef Hprd Interaction: CDT1 — MCM6 (in vivo) Yanagi et al., J Biol Chem 2002*
• IRef Hprd Interaction: CDT1 — MCM6 (in vitro) Yanagi et al., J Biol Chem 2002*
• IRef Hprd Interaction: CDT1 — MCM6 (two hybrid) Yanagi et al., J Biol Chem 2002*
• IRef Intact Interaction: CDT1 — MCM6 (physical association, pull down) Wei et al., J Biol Chem 2010*
• IRef Intact Interaction: CDT1 — MCM6 (direct interaction, nuclear magnetic resonance) Wei et al., J Biol Chem 2010*
• IRef Ophid Interaction: CDT1 — MCM6 (aggregation, confirmational text mining) Yanagi et al., J Biol Chem 2002*
• IRef Ophid Interaction: CDT1 — MCM6 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Kawasaki et al., Genes Cells 2006 : However, Mcm2-7p does bind in the presence of exogenous Cdt1p or Cdt1p-Mcm2-7p complex
Wu et al., J Cell Sci 2012 : We demonstrate that disruption of the interaction between Cdt1p and Mcm6p prevents the formation of the MCM complex , excludes Mcm2-7p from the nucleus, and inhibits pre-RC assembly and DNA replication