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PIK3CA — TMED7

Text-mined interactions from Literome

Gesbert et al., J Biol Chem 2000 : The PI3K inhibitor LY-294002 blocks the ability of BCR/ABL to induce p27 ( Kip1 ) down-regulation and inhibits BCR/ABL induced entry into S phase
van Duijn et al., Prostate 2006 (Prostatic Neoplasms) : We compared the involvement of PI3K/PTEN/Akt signaling in the regulation of the cell-cycle regulator p27 ( kip1 ) and investigated the mechanism of PI3K/PTEN/Akt modulation of p27 ( kip1 ) in the prostate cancer cell lines LNCaP, PC346, PC3, and DU145
Park et al., EMBO Rep 2008 : Reconstitution of MEFs with RIP1 downregulates p27 ( Kip1 ) levels in a PI3K dependent manner
Larrea et al., Mol Cell Biol 2008 : PI3K/PKB inhibition rapidly reduced p27pT157 and p27pT198 and dissociated cellular p27-cyclin D1-Cdk4
Li et al., Biomed Environ Sci 2010 : Activation of PI3K/Akt1 pathway and subsequent negative regulation of p21 ( WAF1/CIP1 ) and p27 ( KIP1 ) expression might be involved in CagA associated carcinogenesis
Wen et al., Oncogene 2012 (Helicobacter Infections...) : These results show that H. pylori infection induces AKT/PI3K mediated phosphorylation of p27 at T157 and T198 to cause cytoplasmic p27 mislocalization in gastric cancer, and that p27 mislocalization is an adverse prognostic feature in gastric cancer