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TLR7 — TLR9

Pathways - manually collected, often from reviews:

• Reactome Reaction: TLR9 → TLR7 (reaction) Li et al., Proc Natl Acad Sci U S A 2002, Kollewe et al., J Biol Chem 2004, Kawai et al., Nat Immunol 2004, Cheng et al., Biochem Biophys Res Commun 2007, Kawagoe et al., J Exp Med 2007, Matsumoto et al., Biochem Biophys Res Commun 2008, Kawagoe et al., Nat Immunol 2008, Ning et al., Mol Cell Biol 2008, Ewald et al., Nature 2008, Park et al., Nat Immunol 2008, Ewald et al., J Exp Med 2011

Text-mined interactions from Literome

An et al., Immunology 2002 : While inhibition of extracellular signal related kinase and NF-kappaB activation suppressed the up-regulation of the expression of TLR2, TLR4 and TLR9 mRNA, inhibition of p38 kinase prevented the up-regulation of TLR2 and TLR4 mRNA expression but enhanced the up-regulation of TLR9 expression
Duez et al., Eur J Dermatol 2006 (Asthma...) : During the allergic reaction, TLR engagement on DC directs the polarization of the T cell response and, while TLR2 and TLR4 may favour both Th1 and Th2 responses, TLR9 induces the development of regulatory T cells
Wang et al., J Biol Chem 2006 (Inflammation) : The results indicate that TLR8 inhibits TLR7 and TLR9, and TLR9 inhibits TLR7 but not vice versa in HEK293 cells transfected with TLRs in a pairwise combination
Sel et al., J Immunol 2007 (Asthma...) : These data indicate that TLR-3 or TLR-7 activation by viral TLR ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10
van de Veerdonk et al., Immunobiology 2008 (Candidiasis) : In conclusion, TLR9 is a pathogen-recognition receptor for C. albicans, and TLR9 is involved in the induction of cytokines in response to C. albicans
Nickerson et al., J Immunol 2010 (Lupus Erythematosus, Systemic) : TLR9 regulates TLR7- and MyD88 dependent autoantibody production and disease in a murine model of lupus ... We previously found that Tlr7 was required for anti-Sm and Tlr9 for anti-chromatin autoantibodies
Kim et al., FEMS Microbiol Lett 2012 (Inflammation) : L. plantarum genomic DNA mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of toll-like receptor (TLR) 2, TLR4, and TLR9 and the induction of interleukin-1 receptor associated kinase M, a negative regulator of TLR
Kwissa et al., Blood 2012 : In the draining lymph nodes ( LNs ), consistent with the effects in blood, all TLR-Ls induced expansion of CD14 ( + ) monocytes, but only TLR7/8-L and TLR9-L expanded the activated CD14 ( + ) CD16 ( + ) cells ... In the draining lymph nodes ( LNs ), consistent with the effects in blood, all TLR-Ls induced expansion of CD14 ( + ) monocytes, but only TLR7/8-L and TLR9-L expanded the activated CD14 ( + ) CD16 ( + ) cells
Celhar et al., Immunol Res 2012 (Disease Models, Animal...) : Data from mouse models suggest a pathogenic role for TLR7 and a protective role for TLR9 in the pathogenesis of SLE
Sacre et al., Arthritis Res Ther 2012 (Lupus Erythematosus, Systemic) : TLR-9 and TLR-7 induced IFN-a and TNF-a production by pDCs was severely impaired in 36 % ( TLR-9 ) and 33 % ( TLR-7 ) of SLE subjects
Zhao et al., Fish Shellfish Immunol 2013 (Ciliophora Infections...) : TLR9 was induced in the skin and gill, whereas TLR21 was induced in the head kidney and spleen after infection
Römmler et al., J Immunol 2013 : Whereas TLR9 induced TNF-a secretion of bone marrow derived macrophages and conventional dendritic cells was equally inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888, TLR7 induced TNF-a release and TLR7- and TLR9 induced IL-12p40 release were significantly more impaired by G-modified INH-ODNs