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PDGFB — PLCG1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database PDGFR-beta signaling pathway:
PLCgamma1 (PLCG1)
→
PDGF-BB/PDGFRB (dimer)/CBL complex (PDGFRB-CBL-PDGFB)
(modification, collaborate)
Broome et al., Oncogene 1999*, Kim et al., Cell 1991*, Reddi et al., J Biol Chem 2007*, Valius et al., Mol Cell Biol 1993*
Evidence: assay, physical interaction, other species
-
NCI Pathway Database PDGFR-beta signaling pathway:
PLCgamma1 (PLCG1)
→
PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB)
(modification, collaborate)
Broome et al., Oncogene 1999*, Kim et al., Cell 1991*, Reddi et al., J Biol Chem 2007*, Valius et al., Mol Cell Biol 1993*
Evidence: assay, physical interaction, other species
-
NCI Pathway Database PDGFR-beta signaling pathway:
PLCgamma1 (PLCG1)
→
PDGF-BB/PDGFRB (dimer)/PLCgamma1 complex (PDGFRB-PLCG1-PDGFB)
(modification, collaborate)
Broome et al., Oncogene 1999*, Kim et al., Cell 1991*, Reddi et al., J Biol Chem 2007*, Valius et al., Mol Cell Biol 1993*
Evidence: assay, physical interaction, other species
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer)/CBL complex (PDGFRB-CBL-PDGFB)
→
PDGF-BB/PDGFRB (dimer)/PLCgamma1 complex (PDGFRB-PLCG1-PDGFB)
(modification, collaborate)
Broome et al., Oncogene 1999*, Kim et al., Cell 1991*, Reddi et al., J Biol Chem 2007*, Valius et al., Mol Cell Biol 1993*
Evidence: assay, physical interaction, other species
-
NCI Pathway Database PDGFR-beta signaling pathway:
PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB)
→
PDGF-BB/PDGFRB (dimer)/PLCgamma1 complex (PDGFRB-PLCG1-PDGFB)
(modification, collaborate)
Broome et al., Oncogene 1999*, Kim et al., Cell 1991*, Reddi et al., J Biol Chem 2007*, Valius et al., Mol Cell Biol 1993*
Evidence: assay, physical interaction, other species
-
NCI Pathway Database PDGFR-beta signaling pathway:
CBL (CBL)
→
PDGF-BB/PDGFRB (dimer)/PLCgamma1 complex (PDGFRB-PLCG1-PDGFB)
(modification, collaborate)
Broome et al., Oncogene 1999*, Kim et al., Cell 1991*, Reddi et al., J Biol Chem 2007*, Valius et al., Mol Cell Biol 1993*
Evidence: assay, physical interaction, other species
-
NCI Pathway Database S1P1 pathway:
PDGF-BB/PDGFRB (dimer)/PLCgamma1 complex (PLCG1-PDGFRB-PDGFB)
→
PLCgamma1 (PLCG1)
(modification, collaborate)
Olivera et al., FASEB J 1999*
-
NCI Pathway Database S1P1 pathway:
PDGF-BB/PDGFRB (dimer)/PLCgamma1 complex (PLCG1-PDGFRB-PDGFB)
→
PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB)
(modification, collaborate)
Olivera et al., FASEB J 1999*
-
NCI Pathway Database S1P1 pathway:
PLCgamma1 (PLCG1)
→
PDGF-BB/PDGFRB (dimer) complex (PDGFRB-PDGFB)
(modification, collaborate)
Olivera et al., FASEB J 1999*
-
NCI Pathway Database S1P1 pathway:
PDGF-BB/PDGFRB (dimer)/PLCgamma1 complex (PLCG1-PDGFRB-PDGFB)
→
SPHK1 (SPHK1)
(modification, activates)
Olivera et al., FASEB J 1999*
Evidence: mutant phenotype, assay
-
NCI Pathway Database PDGFR-beta signaling pathway:
None
→
PDGF-BB/PDGFRB (dimer)/PLCgamma1 complex (PDGFRB-PLCG1-PDGFB)
(modification, collaborate)
Kim et al., Cell 1991*
Evidence: assay
-
Reactome Reaction:
PDGFB
→
PLCG1
(reaction)
Carpenter et al., Exp Cell Res 1999, Rönnstrand et al., EMBO J 1992*, Meisenhelder et al., Cell 1989, Kashishian et al., Mol Biol Cell 1993*, Heldin et al., Biochim Biophys Acta 1998
-
Reactome Reaction:
PDGFB
→
PLCG1
(indirect_complex)
Carpenter et al., Exp Cell Res 1999, Rönnstrand et al., EMBO J 1992*, Meisenhelder et al., Cell 1989, Kashishian et al., Mol Biol Cell 1993*, Heldin et al., Biochim Biophys Acta 1998
Text-mined interactions from Literome
Sachinidis et al., Br J Pharmacol 2000
:
Furthermore CTX attenuated the
PDGF-BB induced tyrosine phosphorylation of the PDGF-Rbeta, PI 3'-K,
PLC-gamma1 and ERK1/2 indicating an action of cyclic AMP on PDGF-beta receptor
Kim et al., Biochem Pharmacol 2005
:
Pre-incubation of rat aortic VSMCs with luteolin significantly inhibited the
PDGF-BB induced extracellular signal regulated kinase 1/2 ( ERK1/2 ), Akt and phospholipase C
(PLC)-gamma1 activation as well as c-fos gene expression
Kim et al., Arch Pharm Res 2006
:
Pre-incubation of the VSMCs with L7G significantly inhibited the
PDGF-BB induced extracellular signal regulated kinase 1/2 ( ERK1/2 ), Akt and the phospholipase C
(PLC)-gamma1 activation
Kim et al., Biol Pharm Bull 2010
(Cardiovascular Diseases) :
In Western blot analysis,
PDGF-BB stimulated ( 25 ng/ml )
phospholipase-C (PLC)gamma1 and Akt phosphorylation was inhibited by BST406 ( 0-10microM )
Inui et al., J Biol Chem 1993
:
At 37 degrees C,
PDGF-AB caused tyrosine phosphorylation of a group of proteins including PDGF-beta receptor and
phospholipase C-gamma 1 , but at a slower rate than PDGF-BB
Sachinidis et al., Eur J Cell Biol 1996
:
GM2 and GM1 inhibit the
PDGF-BB dependent receptor tyrosine autophosphorylation, stimulation of the
PLC-gamma 1 , increase of inositol-1,4,5-trisphosphate ( InsP3 ), elevation in cytosolic free Ca2+ ( [ Ca2+ ] i ), expression of the immediate early growth response gene c-fos and cell proliferation with the following rank order of potency GM2 > GM1 ... Although GM3 did not influence the
PDGF-BB dependent receptor autophosphorylation and
PLC-gamma 1 activation, it effectively inhibited the PDGF-BB dependent InsP3 formation, [ Ca2+ ] i and cell growth ... GM3 was able to suppress the
PDGF-BB dependent increase of InsP3 and [ Ca2+ ] i downstream of the PDGF-BB dependent receptor autophosphorylation and
PLC-gamma 1 activity