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MKL1 — TLR4

Text-mined interactions from Literome

Sacre et al., Am J Pathol 2007 (Arthritis, Rheumatoid...) : Because TLR2 and TLR4 require both MyD88 and Mal/TIRAP for signaling, this study suggests that TLR function may regulate the expression of these factors in the RA synovium
Piao et al., J Biol Chem 2008 : In this study we examined whether tyrosine phosphorylation of Mal regulates its interactions with TLR4 , MyD88, interleukin-1 (IL-1) receptor associated kinase ( IRAK)-2, and tumor necrosis factor receptor associated factor ( TRAF)-6 and is important for signaling
Santos-Sierra et al., EMBO J 2009 : In contrast to TLR2/6, TLR2/1 does not require Mal or MyD88 for Akt phosphorylation
Cekic et al., J Biol Chem 2009 : TLR4 stimulation by lipopolysaccharide can cause both MAL/MyD88- and TRAM/TRIF ( Toll IL-1 receptor domain containing adaptor inducing IFNbeta ) -dependent signaling events