Marchesini et al., J Biol Chem 2004
:
Down-regulation of nSMase2 with siRNA largely prevented the dephosphorylation of the retinoblastoma protein and the induction of p21 ( WAF1 ), providing a link between the action of nSMase2 and key regulators of cell cycle progression
Clarke et al., J Biol Chem 2011
:
Surprisingly, neither ATRA stimulation nor nSMase2 overexpression had significant effects on classical cell cycle regulators such as p21/WAF1 or retinoblastoma