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EPX — MAPK3

Text-mined interactions from Literome

Sui et al., Br J Haematol 2000 : We have recently demonstrated that SCF and EPO synergistically activate mitogen activated protein ( MAP ) kinase , thereby promoting growth of human erythroid colony forming cells ( ECFCs )
Zhande et al., Am J Physiol Heart Circ Physiol 2007 : EPO also activates extracellular signal regulated kinase 1 and 2 ( ERK1/2 ), which are involved in a Bcl-x ( L ) -independent cytoprotective pathway
Jeong et al., Int J Cancer 2008 (Ovarian Neoplasms) : The EpoR on A2780 cells was shown to be functional, since Epo stimulation resulted in phosphorylation of Erk1/2 , an important EpoR mitogenic signaling intermediate
Lee et al., Cancer Res 2011 (Lymphatic Metastasis...) : These effects were abrogated by cotreatment with specific inhibitors of phosphoinositide 3-kinase or mitogen activated protein kinase, under conditions in which EPO increased Akt and extracellular signal regulated kinase 1/2 phosphorylation
Klingmüller et al., Eur J Biochem 1997 : The signal emanating from Y479 involves sequential EPO induced recruitment of phosphoinositol lipid 3-kinase to the EPO-R and activation of mitogen-activated-protein ( MAP ) kinase activity
Sui et al., Blood 1998 : Together, the data suggest that synergistic activation of MAPK by SCF and EPO is essential for expanded erythropoiesis