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CTNNB1 — DKK1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Grotewold et al., EMBO J 2002
:
Taken together, our results provide evidence for an important role of
Dkk-1 mediated inhibition of
Wnt/beta-catenin signaling in response to different stress signals that all converge on the activation of c-Jun in vivo
Mao et al., Nature 2002
:
Wnt/beta-catenin signalling is
inhibited by the secreted protein
Dickkopf1 (Dkk1) , a member of a multigene family, which induces head formation in amphibian embryos
González-Sancho et al., Oncogene 2005
(Colonic Neoplasms) :
We show that activation of canonical signaling by Wnt1 or ectopic expression of active
beta-catenin , TCF4 or LRP6 mutants
induces transcription of the human
DKK-1 gene
Yamaguchi et al., J Dermatol Sci 2005
:
The higher expression of
dickkopf 1 (DKK1) , an
inhibitor of canonical
Wnt/beta-catenin signals, in the plantar dermis partly explains these phenomena
Bryja et al., Cell Signal 2007
:
The increase in
beta-catenin activation by Wnt-3a ( PS-Dvl dependent or -independent ) were
blocked by
Dickkopf1 (Dkk1) , suggesting that the effect of Wnt-3a is in both cases mediated by Lrp5/6 receptors
Yokoyama et al., Dev Biol 2007
:
To test whether Wnt/beta-catenin signaling is required for limb regeneration, we created transgenic X. laevis tadpoles that express
Dickkopf-1 (Dkk1) , a specific
inhibitor of
Wnt/beta-catenin signaling, under the control of a heat-shock promoter
Katoh et al., Cancer Biol Ther 2007
(Helicobacter Infections...) :
WNT-beta-catenin-TCF/LEF signaling
induces upregulation of MYC, CCND1, WISP1, FGF20, JAG1 and
DKK1 genes
Koppen et al., Cancer Lett 2007
(Neuroblastoma) :
Surprisingly,
DKK1 expression did not
inhibit the canonical
wnt/beta-catenin signalling, suggesting a role of DKK1 in an alternative route of the wnt pathway
Yamaguchi et al., FASEB J 2008
:
Dickkopf 1 (DKK1) regulates skin pigmentation and thickness by affecting
Wnt/beta-catenin signaling in keratinocytes ...
DKK1 induced the expression of keratin 9 and alpha-Kelch-like ECT2 interacting protein ( alphaKLEIP ) but
down-regulated the expression of
beta-catenin , glycogen synthase kinase 3beta, protein kinase C, and proteinase activated receptor-2 (PAR-2), which is consistent with the expression patterns of those proteins in human palmoplantar skin
Peng et al., Reproduction 2008
:
Taken together,
Dkk1 secreted by decidual cells may induce trophoblast cell invasion in the mouse and
beta-catenin may be
involved in such functions of Dkk1
Pinzone et al., Blood 2009
(Bone Diseases) :
Dickkopf-1 (DKK1) , a soluble
inhibitor of
Wnt/beta-catenin signaling required for embryonic head development, regulates Wnt signaling by binding to the Wnt coreceptor lipoprotein related protein-5 (LRP5)/Arrow
Yasuhara et al., J Biol Chem 2010
:
This stimulation was accompanied by increased gene expression of Wnt proteins and receptors and was inhibited by co-treatment with
Dickkopf related protein-1 , an extracellular
inhibitor of
Wnt/beta-catenin signaling, suggesting that RA modulates Wnt signaling at Wnt cell surface receptor level
Kamiya et al., J Bone Miner Res 2010
:
These results demonstrate that BMPRIA in osteoblasts negatively regulates endogenous bone mass and
Wnt/beta-catenin signaling and that this regulation may be
mediated by the activities of Sost and
Dkk1
Wang et al., Biochem Biophys Res Commun 2009
:
A loss of
beta-catenin induced by
Dickkopf-1 can enhance MSCs differentiation into epithelial cells
Navarro et al., Carcinogenesis 2010
(Cell Transformation, Neoplastic...) :
We present evidence demonstrating that the Wnt inhibitor and beta-catenin/T-cell factor ( TCF ) -responsive gene DICKKOPF-1 (DKK-1) is a transcriptional target of EWS/FLI1, which can inhibit both basal and
beta-catenin induced transactivation of the
DKK-1 promoter
Lin et al., J Am Soc Nephrol 2010
(Diabetes Mellitus, Experimental...) :
DKK1 mediated HG-induced phosphorylation of Ser45-beta-catenin and reduction of nuclear
beta-catenin levels, but not phosphorylation of ERK kinase
Mitra et al., J Biol Chem 2010
(Neoplasm Metastasis) :
We found that MRJ ( L ) up-regulates expression of
DKK1 , a well known
Wnt/beta-catenin signaling
inhibitor , that causes degradation of beta-catenin