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CTNNB1 — GYS2
Text-mined interactions from Literome
Sakanaka et al., Recent Prog Horm Res 2000
(Neoplasms) :
This regulation of cytosolic
beta-catenin is
mediated by
glycogen synthase kinase-3 ( GSK-3 ) activity but in neither case is the mechanism known
Kaidanovich-Beilin et al., Biol Psychiatry 2004
(Disease Models, Animal) :
Rapid antidepressive-like activity of specific
glycogen synthase kinase-3 inhibitor and its
effect on
beta-catenin in mouse hippocampus
Patel et al., Cancer Cell 2008
(Leukemia) :
Dogma held that inhibition of the pleiotropic protein kinase
glycogen synthase kinase-3 ( GSK-3 ) was procarcinogenic
due to its natural repression of
beta-catenin
Huang et al., J Mol Biol 2009
:
Wnt3A,
glycogen synthase kinase 3beta inhibitors or mutation of CSN mediated deneddylation
induce the disassembly of the supercomplex and the accumulation of
beta-catenin
Iseki et al., Cancer Sci 2010
:
Interestingly, luciferase reporter analysis and quantitative real-time RT-PCR demonstrated that the ALEX1 promoter was up-regulated in a CRE dependent manner by continuous activation of
Wnt/beta-catenin signaling
induced by a
glycogen synthase kinase-3 inhibitor and overexpression of beta-catenin
Torres et al., Mol Cell Biol 1999
:
In developing embryos and in some human cancers, the accumulation of
beta-catenin in the cytoplasm and subsequently the nuclei of cells may be
regulated by the Wnt-1 signaling cascade and by
glycogen synthase kinase 3 ( GSK-3 )