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PRL — RLN2

Text-mined interactions from Literome

Peters et al., Mol Endocrinol 2000 : The ability of PRL or rat placental lactogen ( rPL ) -1 to induce relaxin mRNA expression was analyzed in a luteinized rat granulosa cell culture model ... PRL receptor activation induced relaxin mRNA expression in a concentration- and time dependent manner ... Estrogen enhanced relaxin expression induced by PRL but did not affect relaxin expression on its own ... Taken together, these results show that PKC delta is obligatory for PRL/rPL-1 dependent relaxin expression, that PKC delta complexes with Stat 3 in response to PRL receptor activation, and that PKC delta is involved in the regulation of Stat 3 phosphorylation downstream of the PRL receptor
Concannon et al., J Reprod Fertil Suppl 2001 : It is not known whether relaxin can stimulate prolactin secretion in dogs
Handwerger et al., Ann N Y Acad Sci 1991 : In addition, the synthesis and release of decidual prolactin are stimulated by IGF-I, insulin and relaxin , each acting through distinct plasma membrane receptors ... The demonstration that the synthesis and release of decidual prolactin are regulated by PRL-RF, IGF-I, insulin, relaxin , arachidonic acid, PRL-IF and lipocortin I strongly suggests that there is novel autocrine/paracrine feedback regulation between the placenta, fetal membranes, and decidua in the regulation of decidual prolactin
Sortino et al., Endocrinology 1989 : PRL secretion was significantly stimulated 1.31-fold by human relaxin at the lowest concentration studied ( 30 pM ) and maximally stimulated 1.65-fold at 0.3 nM relaxin
Bethea et al., J Clin Endocrinol Metab 1989 : These data suggest that relaxin can stimulate secretion of GH and PRL in cycling monkeys within a defined dose range, but that a decrease in pituitary responsiveness occurs at higher doses
Huang et al., Endocrinology 1987 : Regulation of prolactin production by progestin, estrogen, and relaxin in human endometrial stromal cells ... We identified the PRL synthesized in endometrial stromal cells and investigated the effect of medroxyprogesterone acetate ( MPA ), estradiol ( E2 ), porcine relaxin ( RLX ) , and RU486, an antiprogestin, on PRL production by stromal cells from non-pregnant endometrium in primary culture ... In the presence of MPA or MPA and E2, 0.1 ng/ml relaxin increased the PRL production rate
Schmidt et al., Eur J Obstet Gynecol Reprod Biol 1984 : In vitro studies did not evidence significant relaxin production by either decidual or placental tissues, even in the presence of decidual prolactin production
Lessing et al., Obstet Gynecol 1984 : The current study was designed to determine the effect of rat prolactin on rat uterine horn segment contractility and its interaction with relaxin
Telgmann et al., Endocrinology 1997 : In a primary ES cell culture system we show that relaxin not only acutely but permanently elevates cellular cAMP levels and leads to induction of PRL secretion after 6 days Northern and Western blot analyses revealed that all regulatory subunit isoforms ( RI alpha, RI beta, RII alpha, and RII beta ) and catalytic subunits C alpha and C beta of protein kinase A (PKA) are expressed in ES cells