◀ Back to JUN

JUN — PLAT

Text-mined interactions from Literome

Yang et al., Endocrine 2008 : We have analyzed a possible role of mitogen activated protein kinase ( MAPK ) and activator protein-1 (AP-1) in the regulation of FSH induced tissue type plasminogen activator (tPA) production in granulosa cells (GCs) prepared from DES treated immature rats ; Treatment of the cells in the presence of FSH with MAPK inhibitors, such as UO126 or SB203580, significantly decreased the FSH induced tPA production, suggesting that multiple signaling pathways may be involved in FSH regulated tPA expression ... We further examined whether AP-1 located in the tPA promoter is involved in FSH regulated tPA production, and demonstrated that FSH significantly stimulated AP-1 expression, whereas inclusion of H89, UO126, or SB20358 in the culture significantly decreased FSH induced AP-1 expression
Pineda et al., Glia 2012 (MAP Kinase Signaling System) : We found that tPA induces a catalytic independent rapid and sustained activation of extracellular signal regulated kinase ( ERK ) 1/2, Jun N-terminal kinase (JNK) , Akt, and p38 signaling pathways