Nakagawa et al., American journal of physiology. Renal physiology 2004
(Anoxia) :
Rat proximal tubular ( NRK52E ) cells treated with TGF-beta under normoxic conditions secreted VEGF at 24 h, and this was significantly reduced by blocking Smad activation by overexpressing the inhibitory Smad7 or by blocking p38 and ERK1/2 MAP kinase activation or protein kinase C activation with specific inhibitors
Lee et al., Cell Tissue Res 2012
(Glomerulonephritis, Membranous...) :
Furthermore, activated TGF-ß/Smad signaling by podocytes may induce connective tissue growth factor and vascular endothelial growth factor overexpression, which could act as a paracrine effector mechanism on mesangial cells to stimulate mesangial matrix synthesis
Bai et al., Development 2013
(Truncus Arteriosus, Persistent...) :
Our findings indicate that Smad directly binds to Vegfa chromatin and represses Vegfa transcriptional activity