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GSK3B — HGF
Text-mined interactions from Literome
Liu et al., FASEB J 2002
:
Pharmacological inhibitor studies demonstrated each pathway to be intimately involved in
HGF induced increases in TER, cortical actin thickening, and phosphorylation of the Ser/Thr
glycogen synthase kinase-3beta ( GSK-3beta ), a potential target for the HGF barrier promoting response
Lim et al., Cell Signal 2008
:
Conversely, pharmacological inhibition of c-Met with its specific inhibitor, PHA-665752, or genetic knock-down of c-Met with short hairpin RNAs ( shRNAs ) suppressed
HGF induced phosphorylation of Akt and
GSK-3beta , increased phosphorylation of MAP2, and reduced dendrite number and length in cultured hippocampal neurons ... Inhibiting Akt activity with the phosphoinositide-3-kinase inhibitor LY294002 or Akt inhibitor X suppressed
HGF induced phosphorylation of
GSK-3beta , increased MAP2 phosphorylation, and blocked the ability of HGF to enhance dendritic length
Giannopoulou et al., Am J Pathol 2008
(Inflammation...) :
HGF also
induced renal
GSK-3beta phosphorylation and inactivation after obstructive injury in vivo
Papkoff et al., Biochem Biophys Res Commun 1998
:
WNT-1 and
HGF regulate
GSK3 beta activity and beta-catenin signaling in mammary epithelial cells