Zhou et al., Int J Oncol 2006
(Ovarian Neoplasms) :
TSA transiently activated EGFR tyrosine phosphorylation and AKT activation in a time- and dose dependent manner, which had been inhibited by EGFR inhibitor PD153035 and PI3 kinase inhibitor LY294002
Park et al., Biochem Pharmacol 2009
(Ovarian Neoplasms) :
TSA or co-treatment with TSA alone and TRAIL also resulted in down-regulation of EGFR1/2 and dephosphorylation of its downstream targets, AKT and ERK
Cervelli et al., Stem Cells Transl Med 2012
:
PRP with insulin synergistically upregulated fibroblast growth factor receptor ( FGFR ) and downregulated epidermal growth factor receptor ( ErbB ) expression ; moreover, PRP in association prevented insulin induced insulin-like growth factor-1 receptor and insulin receptor downregulation