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APOB — GPI

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Dart et al., Cardiovasc Res 1999 (Cardiovascular Diseases) : Thus, oxidised LDL affects endothelial ET1 and PGI2 release
Smith et al., Arterioscler Thromb Vasc Biol 2002 : This alteration in PGI2 production did not result from LDL induced changes in PGI2 synthase expression
Norata et al., Int J Mol Med 2004 : N-LDL and Ox-LDL increased PGE2 release in a Cox-2 dependent manner while TXA2 and PGI2 release were not affected either by n-LDL or Ox-LDL
Hu et al., Chin Med Sci J 1991 : Although LDL at comparable cholesterol concentrations to HDL also results in an increase of PGI2 synthesis in a dose dependent pattern, the extent of this increase is much less than that induced by HDL
Magyari et al., Fortschr Ophthalmol 1990 (Diabetes Mellitus, Type 1...) : There was a positive correlation between PSA and HDL cholesterol values and a negative correlation between PSA and LDL cholesterol levels, which is related to the inhibitory effect of LDL and the protective role of HDL in PGI2 synthesis
Galle et al., Eicosanoids 1990 : We have studied the effects of low density lipoproteins (LDL) on the intracellular free calcium concentration [ ( Ca2+ ] i, measured with the fluorescent probe indo-1 ) and PGI2 release ( measured with radioimmunoassay of 6-keto PGF1 alpha ) in cultured endothelial cells from bovine aorta
Hu et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 1989 (Hyperlipidemias) : Although LDL at comparable cholesterol concentrations of HDL also induced increase in PGI2 synthesis in a dose dependent pattern, the extent was much less than that of HDL
Beitz et al., Biomed Biochim Acta 1988 (Hyperlipidemias) : This difference, however, is not responsible for the enhanced ability of LDL from men versus LDL from women to inhibit PGI2 formation ... Secondly, LDL from hyperlipidemic men type II a did not inhibit PGI2 formation, but the level of testosterone in the LDL of these volunteers is significantly higher than in LDL from healthy men
Shakhov et al., Biokhimiia 1988 (Coronary Disease) : Estradiol ( 1.10 ( -7 ) M ) showed a stimulating effect ; norepinephrine ( 1.10 ( -6 ) M ) and progesterone ( 1.10 ( -7 ) M ) showed an inhibiting effect, whereas corticosterone ( 1.10 ( -6 ) M ) and deoxycorticosterone ( 1.10 ( -6 ) M ) did not influence the rate of LDL dependent PGI2 synthesis
Triau et al., Arteriosclerosis 1988 : However, among these prostanoids, mainly PGI2 was produced in response to Ox-LDL ... The data indicate that Ox-LDL induces the production of PGI2 by human vascular endothelial cells
Giessler et al., Prostaglandins Leukot Med 1986 : LDL of male donors inhibited endogenous PGI2-formation and the conversion of exogenous PBH2 to PGI2
Beitz et al., Prostaglandins 1985 : Earlier we found LDL and HDL to differentially affect the synthesis of PGI2 from PGH2 by pig aorta microsomes and that this depended on the gender of the lipoprotein donors
Spector et al., J Lipid Res 1985 : The stimulatory effect of HDL3 and LDL on PGI2 production decreased as growing cultures became confluent ... Furthermore, the amount of PGI2 formation elicited by the lipoproteins in 18 hr was 4-fold less than that produced during incubation with a fatty acid mixture containing only 5 % arachidonic acid, and 3-fold less than when the cells were stimulated with the ionophore A23187 for 20 min. Taken together, our results indicate that human HDL and LDL contribute to endothelial PGI2 production only in a modest way and suggest that this process is not specific for either of these two plasma lipoproteins
Mest et al., Klin Wochenschr 1983 : HDL taken from serum before and after 3 weeks of linseed oil diet and LDL taken after 3 weeks of diet stimulated the PGI2 formation in PAM, whereas LDL taken from serum before the diet period inhibited the PGI2 formation in PAM
Beitz et al., Prostaglandins 1983 (Hyperlipoproteinemia Type II...) : 3 ) LDL isolated from healthy men inhibited in dose dependent fashion the generation of PGI2 from PGH2 by aortic microsomes whereas LDL from premenopausal women stimulated PGI2 formation even calculated as LDL lipid peroxides ( in nM MDA/ml )
Ishikawa et al., J Clin Invest 1994 : AVP caused a biphasic change in cellular pH ( pHi ), namely, an early acidification followed by a sustained alkalinization, and the change in pHi produced by AVP was also enhanced by LDL
Sinzinger et al., Prostaglandins 1996 (Hypercholesterolemia) : It is concluded that the improved LDL binding by the liver is due to an enhanced PGI2-formation evoked by isradipine
Myers et al., Am J Physiol 1996 : Modified low-density lipoprotein (LDL) increased PGI2 production in the short term ( up to 24 h ), but oxidized LDL caused an inhibition of PGI2 producing capacity in longer term incubations ( 48-72 h )
Jay et al., Exp Physiol 1997 : In contrast, highly oxidized LDL inhibited histamine stimulated release of NO and PGI2 from human endothelial cells and induced an adaptive increase in the level of intracellular glutathione in human smooth muscle cells, a response which was prevented by the chain breaking antioxidant alpha-tocopherol
Li et al., Arterioscler Thromb Vasc Biol 1997 (Peripheral Vascular Diseases) : Our results suggest a direct effect of modified LDL on PGE2, PGE1, and PGI2 binding onto monocytes by reducing the number of cell surface expressed receptors available