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ANXA6 — PRKAB1
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Krause et al., Eur J Biochem 2002
:
In this paper, we studied the
effect of
AMPK activation and of protein phosphatase inhibitors, on the amino-acid induced activation of
p70S6K and ACC in hepatocytes in suspension
Horman et al., J Biol Chem 2003
(Anoxia...) :
Rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR), did not mimic the effect of oxygen deprivation to inhibit protein synthesis in cardiomyocytes or lead to eEF2 phosphorylation in perfused hearts, suggesting that
AMPK activation did not
inhibit mTOR/p70 ribosomal protein S6 kinase (p70S6K) signaling
Chan et al., J Biol Chem 2004
(Hypertrophy) :
Activation of
AMPK also
resulted in decreased
p70S6 kinase phosphorylation and increased phosphorylation of eEF2, suggesting that inhibition of protein synthesis involves the eEF2 kinase/eEF2 axis and/or the p70S6 kinase pathway
Habib et al., Eur J Cancer 2010
(Kidney Neoplasms) :
Downregulation of
AMPK phosphorylation by high glucose ( HG )
increases the phosphorylation of
p70S6K and decreases the protein expression of NF-YA and OGG1
Demeulder et al., Biochim Biophys Acta 2013
(Myocardial Ischemia) :
This challenges the accepted notion that
mTOR-p70S6K is inhibited by myocardial ischemia mainly via an
AMPK dependent mechanism