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CXADR — PTH

Text-mined interactions from Literome

Hoppe et al., Przegl Lek 2000 (Calcium Metabolism Disorders) : It was shown that stimulation of CaR induced by an increase of extracellular ionized calcium concentration resulted in an increase of intracellular calcium and subsequent decrease of parathyroid hormone (PTH) secretion from parathyroid cells
Ritter et al., J Bone Miner Res 2004 (Calcium Signaling) : CaR mRNA and the calcium regulation of PTH secretion were measured over a period of several weeks in parathyroid cells cultured both in collagen matrix and as monolayers
Drüeke et al., Nephrol Dial Transplant 2004 : In the parathyroid gland cell, activation of the CaR by elevated serum levels of calcium leads to a decrease in PTH secretion
Ureña Torres et al., Nephrol Dial Transplant 2004 (Hyperparathyroidism, Secondary...) : Activation of the CaR results in a rapid reduction in PTH secretion
Quinn et al., Biochem Biophys Res Commun 2007 : The calcium sensing receptor (CaR) mediates the effects of extracellular calcium ( [ Ca ( 2+ ) ] ( o ) ) on PTH release, such that increasing levels of [ Ca ( 2+ ) ] ( o ) inhibit PTH secretion through poorly defined mechanisms
McCormick et al., J Biol Chem 2010 (Calcium Signaling) : Finally, the phosphatase inhibitor calyculin-A reversed CaR induced inhibition of parathyroid hormone secretion from bovine parathyroid slices and normal human parathyroid cells, demonstrating the physiological importance of phosphorylation status on parathyroid function
Brown et al., Annu Rev Med 1998 (Disease...) : In the parathyroid, the CaR mediates the inhibitory effects of Ca2+o on parathyroid hormone (PTH) secretion and likely on expression of the PTH gene and parathyroid cellular proliferation